Registration Dossier
Registration Dossier
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EC number: 211-219-8 | CAS number: 634-93-5
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Classification of 2, 4, 6-trichloroaniline for effects in the environment
In determining the classification appropriate to 2,4,6-trichloroaniline, it is necessary to consider all available evidence concerning its persistence, potential to accumulate and predicted or observed environmental fate and behaviour that may present a long-term and/or delayed danger to the structure and/or functioning of aquatic ecosystems. These points are considered below.
Persistence
Reliable studies are available to demonstrate that 2,4,6-trichloroaniline is persistent in the aquatic environment. Moreover, its persistent characteristics (based on WOE) is also observe in the sediment and soil compartment and hence it has been concluded that 2,4,6-trichloroaniline is persistent in nature. However, since there is no identified diffusion of the substance in the sediment and hence persistence in the sediment compartment is not likely to be critical.
2,4,6-trichloroaniline is classified as a persistent (P) chemical.
Potential to accumulate
The estimated log Kow values for 2,4,6-trichloroaniline is less than 4 (Log Kow = 3.52). The potential for 2,4,6-trichloroaniline to bioaccumulate in the tissues of organisms that inhabit aquatic or terrestrial matrices is negligible as the BCF factor for the substance is less than 2000. The estimated BCF of 2,4,6-trichloroaniline is highest 147 dimensionless and below the threshold of 2000.
Thus, 2,4,6-trichloroaniline does not satisfy the criterion for classification as bio-accumulative (B).
The toxicity values of fish, invertebrates and algae are LC50 = 5.3 mg/L, LC50 = 2.3 mg/L and EC50 = 4.445 mg/L, respectively. These values suggest classification for aquatic toxicity will be applicable for all of the tropic levels. Thus, the chemical is classified in the Aquatic Chronic 2 category.
Also, based upon the repeated dose toxicity and reporoductive toxicity end points, 2,4,6-trichloroaniline satisfies the criteria for classification as toxic (T).
In conclusion, since the chemical is not bio-ccumulative, but persistent and toxic; it can beinferred that 2,4,6-trichloroaniline is not a PBT (including vPvB) substance.
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