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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from safety assessment report

Data source

Reference
Reference Type:
secondary source
Title:
skin irritation and sensitization study
Author:
NTRL Report
Year:
1984
Bibliographic source:
NTRL Report; 04/05/1984

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Skin sensitization study was conducted on guinea pigs for test chemical 2,4,6-trichloroaniline (CAS No: 634-93-5) to determine its sensitization potential.
GLP compliance:
not specified
Type of study:
not specified
Justification for non-LLNA method:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4,6-trichloroaniline
EC Number:
211-219-8
EC Name:
2,4,6-trichloroaniline
Cas Number:
634-93-5
Molecular formula:
C6H4Cl3N
IUPAC Name:
2,4,6-trichloroaniline
Test material form:
solid
Details on test material:
-Name of the test material: 2,4,6-trichloroaniline
- Molecular formula: C6H4Cl3N
- Molecular weight: 196.464 g/mol
- Smiles notation: Nc1c(Cl)cc(Cl)cc1Cl
- InChl : 1/C6H4Cl3N/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,10H2
-Substance type: Organic
-Physical state: solid
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2,4,6-trichloroaniline
- Molecular formula: C6-H4-Cl3-N
- Molecular weight: 196.464 g/mol
- Smiles notation: c1(c(cc(Cl)cc1Cl)Cl)N
- InChl (if other than submission substance): 1S/C6H4Cl3N/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,10H2
- Substance type: organic
- Physical state: Solid

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Study design: in vivo (non-LLNA)

Induction
Route:
other: not specified
Challenge
Route:
other: not specified
No. of animals per dose:
not specified
Details on study design:
not specified
Challenge controls:
not specified

Results and discussion

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
Dose level:
not specified
Clinical observations:
Moderate skin sensitization was observed in treated guinea pigs.
Remarks on result:
positive indication of skin sensitisation

In vivo (LLNA)

Cellular proliferation data / Observations:
Moderate skin sensitization was observed in treated guinea pigs.

Applicant's summary and conclusion

Interpretation of results:
other: sensitizing
Conclusions:
The test material 2,4,6-trichloroaniline (CAS No: 634-93-5) was considered to be sensitizing to the skin of guinea pigs.
Executive summary:

Skin sensitization study was conducted on guinea pigs for test chemical 2,4,6-trichloroaniline (CAS No: 634-93-5) to determine its sensitization potential.

 

When the guinea pigs were treated with test chemical, moderate skin sensitization was observed in treated guinea pigs.

 

Therefore the chemical 2,4,6-trichloroaniline (CAS No: 634-93-5) was considered to be sensitizing to the skin of guinea pigs.