Registration Dossier
Registration Dossier
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EC number: 211-219-8 | CAS number: 634-93-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from Authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: Authoritative database
- Title:
- Acute dermal toxicity study of test chemical was performed in rodents.
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2018
- Reference Type:
- other: Authoritative database
- Title:
- Acute dermal toxicity study of test chemical was performed in rodents.
- Author:
- IFA GESTIS
- Year:
- 2 018
- Bibliographic source:
- Gestis Substance Database ,2018
- Reference Type:
- review article or handbook
- Title:
- Acute dermal toxicity study of test chemical was performed in rodents.
- Author:
- Food & Agriculture Org.
- Year:
- 1 999
- Bibliographic source:
- Pesticide Residues in Food, Pg. 76,1999
- Reference Type:
- review article or handbook
- Title:
- Acute dermal toxicity study of test chemical was performed in rodents.
- Author:
- S. Gangolli
- Year:
- 1 999
- Bibliographic source:
- The Dictionary of Substances and Their Effects: E-J,D260, 1999
- Reference Type:
- secondary source
- Title:
- Acute dermal toxicity study of test chemical was performed in rodents.
- Author:
- RTECS
- Year:
- 2 018
- Bibliographic source:
- RTECS (registry of toxic effect of chemical substance database), 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity study of test chemical was performed in rodents.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2,6-dichloro-4-nitroaniline
- EC Number:
- 202-746-4
- EC Name:
- 2,6-dichloro-4-nitroaniline
- Cas Number:
- 99-30-9
- Molecular formula:
- C6H4Cl2N2O2
- IUPAC Name:
- 2,6-dichloro-4-nitroaniline
- Details on test material:
- - Name of test material (IUPAC name): 2,6-dichloro-4-nitroaniline
- Common name: Dicloran
- Molecular formula: C6H4Cl2N2O2
- Molecular weight: 207.016 g/mol
- Smiles notation: c1(cc(c(N)c(c1)Cl)Cl)[N+](=O)[O-]
- InChl: 1S/C6H4Cl2N2O2/c7-4-1-3(10(11)12)2-5(8)6(4)9/h1-2H,9H2
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (IUPAC name): 2,6-dichloro-4-nitroaniline
- Common name: Dicloran
- Molecular formula: C6H4Cl2N2O2
- Molecular weight: 207.016 g/mol
- Smiles notation: c1(cc(c(N)c(c1)Cl)Cl)[N+](=O)[O-]
- InChl: 1S/C6H4Cl2N2O2/c7-4-1-3(10(11)12)2-5(8)6(4)9/h1-2H,9H2
- Substance type: Organic
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Type of coverage:
- other: dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- No data
- Duration of exposure:
- No data
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- No data
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed at dose 2000 mg/kg bw
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- The LD50 value was considered to be >2000 mg/kg bw,when rabbits were treated with test chemical by dermal application.
- Executive summary:
In acute dermal toxicity study, rabbits were treated with test chemical in the concentration of 2000 mg/kg bw by dermal application.No mortality was observed in treated rabbits at dose 2000 mg/kg bw.Therefore, LD50 value was considered to be >2000 mg/kg bw,when rabbits were treated with test chemical by dermal application.
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