Registration Dossier
Registration Dossier
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EC number: 236-882-0 | CAS number: 13531-52-7
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The substance is considered to be acutely harmful to aquatic invertebrates.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 25.9 mg/L
Additional information
The acute toxicity of N-(2-aminoethyl)-1,3-propanediamine (CAS 13531-52-7) was studied in a static test with Daphnia magna according to German Industrial Standard test guideline DIN 38412, part 11. The nominal test concentrations were 0 (control), 3.125, 6.25, 12.5, 25.0, 50.0, and 100 mg/L. The study was performed without analytical monitoring, however, it is assumed that the test concentrations remained stable over the exposure period based on the substance's physico-chemical properties adn its environmental fate. The test item is completely miscible with water (measured; see IUCLID Ch. 4.8), which is a pre-requisite to the reliable preparation of the test concentrations. The Substance will be evenly distributed in the test medium. In addition, it is highly unlikely that the Substance will precipitate from the test medium. Evaporation of the test item from the test medium is not to be expected based on the low vapour pressure of 0.036 hPa (measured at 20 °C; see IUCLID Ch. 4.6) and the low Henry's Law constant (4.17E-08 Pa*m³/mol, HENRYWIN v3.20; see IUCLID Ch. 5.4.2). In addition, the Substance is ionized at the environmentally relevant pH range (pKa = 10.51; estimated; see IUCLID Ch. 4.21), which further reduces any tendency of the Substance to evaporate into the atmosphere. Finally, loss of the test item from the test medium due to adsorption to the test vessels is unlikely as the Substance has a low adsorption potential (log Kow = -1.67, measured; see IUCLID Ch. 4.7; log Koc = 0.96 at pH 5 to 8, calculated according to Franco & Trapp; see IUCLID Ch. 5.4.1). The 48h EC50 was determined to be 25.9 mg/L (result based on not pH-adjusted test solutions). The highest test concentration of 100 mg/L was tested in parallel after neutralization. The toxic effect was similar to the not-adjusted test solution (BASF AG, 1989; Study No. 1/0502/2/89-0503/89).
Based on the available information, the substance is considered to be acutely harmful to aquatic invertebrates.
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