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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented and acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
other: BASF-Test
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N-(2-aminoethyl)-1,3-propanediamine
EC Number:
236-882-0
EC Name:
N-(2-aminoethyl)-1,3-propanediamine
Cas Number:
13531-52-7
Molecular formula:
C5H15N3
IUPAC Name:
N1-(2-Aminoethyl)-1,3-propanediamine
Details on test material:


- Name of test material (as cited in study report): N-Momo-(aminopropyl)-1,2-diaminoaethan (N-3-Amin)
- Analytical purity: 98 %

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: male: 20.8 g (mean); female: 20.8 g (mean)

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
464, 215, 147, 100, 46.4 µL/kg; equivalent to 431.2, 199.8, 136.6, 43.1 µg/kg
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
158 mg/kg bw
Based on:
test mat.
Remarks on result:
other: corresponding to 170 µL/kg
Mortality:
After the 14-day observation period, all animals in the lowest dose groups (136.6 and 43.1 µg/kg) survived. In the higher dose group, no female animals died (0/5) but three male animals (3/5) died. After application of 199.8 µg/kg, in both sexes 4/5 animals died within 7 days. At the highest dose, all animals died within 24 hours.
Clinical signs:
dyspnea, apathy, stagger, spastic gait, tremor, tonic convulsions, reduced general conditon
Gross pathology:
intraabdominal adherence

Any other information on results incl. tables

Mortality

 Dose (µl/kg)  Conc. (%)  No. of Animals died within1 h  24 h  48 h  7 d  14 d
 464 4.64   5 male  0/5  5/5  5/5  5/5  5/5
 464  4.64  5 female  0/5  5/5  5/5  5/5  5/5
 215  2.15  5 male  0/5  2/5  3/5  4/5  4/5
 215  2.15  5 female  0/5  2/5  3/5  4/5  4/5
 147  1.47  5 male  0/5  0/5  2/5  3/5  3/5
 147  1.47  5 female  0/5  0/5  0/5  0/5  0/5
 100  1  5 male  0/5  0/5  0/5  0/5  0/5
 100  1  5 female  0/5  0/5  0/5  0/5  0/5
 46.6  0.464  5 male  0/5  0/5  0/5  0/5  0/5
 46.6  0.464  5 female  0/5  0/5  0/5  0/5  0/5

Applicant's summary and conclusion