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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Study period:
1978
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
inhalation hazard test; 8-hour exposure period
Justification for type of information:
A read-across justification is provided in the IUCLID Chapter "Assessment reports"

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Principles of method if other than guideline:
Rats were exposed to a saturated solution for 8 hours and observed for 14 days.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentan-1-ol
EC Number:
200-752-1
EC Name:
Pentan-1-ol
Cas Number:
71-41-0
Molecular formula:
C5H12O
IUPAC Name:
pentan-1-ol
Details on test material:
No additional information available.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
rats were exposed to an essentially saturated solution.
No. of animals per sex per dose:
6
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
other: Inhalation hazard test
Exp. duration:
8 h
Remarks on result:
other: No mortality occurred and no clinical signs were observed when rats were exposed for 8 hours to a saturated atmosphere of test substance vapours.
Mortality:
No mortality was observed in rats exposed to a substantially saturated vapor for 8 hours.
Clinical signs:
other: There were no clinical signs observed during the exposure period or observation period.
Body weight:
Exposed animals gained 53 to 82 g during the observation period.
Gross pathology:
There were no gross pathologic effects noted at the end of the observation period.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
No hazard is anticipated from the infrequent inhalation of substantially saturated vapor generated at room temprature under handlimg conditions.
Executive summary:

A group of 6 rats were exposed to an essentially saturated atmosphere of n-propanol for 8 hours. No significant effects were noted during or following exposure to an essentially saturated atmosphere of n-pentanol.