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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Cardiovascular effects of ethanol, its cogeners and synthetic bourbon in dogs
Author:
Nakano J and Kessinger JM
Year:
1972
Bibliographic source:
European Journal of Pharmacology, 17, 195-201
Reference Type:
publication
Title:
No information
Author:
RIFM
Year:
2009
Bibliographic source:
RIFM database

Materials and methods

Principles of method if other than guideline:
acc. to Nakano (1964, 1967)
GLP compliance:
no
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3-methylbutan-1-ol
EC Number:
204-633-5
EC Name:
3-methylbutan-1-ol
Cas Number:
123-51-3
Molecular formula:
C5H12O
IUPAC Name:
3-methylbutan-1-ol
Details on test material:
- Name of test material (as cited in study report): iso-amyl alcohol
- Source: Fisher Sci. Co., Houston, Texas

Test animals

Species:
dog
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 15 - 30 kg

Administration / exposure

Route of administration:
intravenous
Vehicle:
not specified
Doses:
20 mg/kg bw
No. of animals per sex per dose:
18 animals
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD100
Effect level:
20 mg/kg bw
Mortality:
All dogs expired prior to 1 hour of infusion
Clinical signs:
Heart rate, systemic arterial pressure and myocardial contactile force decreased. Pulmonary arterial pressure increased.

Any other information on results incl. tables

The continuous i.v. infusion of iso-amyl alcohol, 20 mg/kg per min, decreased heart rate, systemic arterial pressure and myocardial contractile force progressively and markedly even when the blood iso-amyl alcohol levels were less than 0.2 mg/ml. With the dose of iso-amyl alcohol infusion, all dogs expired prior to 1 hr infusion. In spite of the marked myocardial depression, mean pulmonary arterial pressure increased slightly.

Applicant's summary and conclusion