Registration Dossier
Registration Dossier
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EC number: 204-633-5 | CAS number: 123-51-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VII
- Author:
- Smyth HF et al.
- Year:
- 1 969
- Bibliographic source:
- Am. Ind. Hyg. J. 30, 470-476
- Reference Type:
- secondary source
- Title:
- Fragrance raw materials monographs - Isoamly alcohol
- Author:
- Opdyke DLJ
- Year:
- 1 978
- Bibliographic source:
- Food Chem. Tox. 16, S1, 785-788
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- RIFM
- Year:
- 2 009
- Bibliographic source:
- RIFM database
Materials and methods
- Principles of method if other than guideline:
- acc. to Smyth HF et al., Am. Ind. Hyg. Assoc. J. 23, 95, 1962
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-methylbutan-1-ol
- EC Number:
- 204-633-5
- EC Name:
- 3-methylbutan-1-ol
- Cas Number:
- 123-51-3
- Molecular formula:
- C5H12O
- IUPAC Name:
- 3-methylbutan-1-ol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
Test system
- Type of coverage:
- open
- Preparation of test site:
- other: clipped
- Vehicle:
- other: undiluted or as a solution in water, propylene glycol or acetone
- Controls:
- not specified
- Amount / concentration applied:
- 0.01 ml
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 24 h
- Number of animals:
- 5
- Details on study design:
- TEST SITE
- Area of exposure: uncovered belly
SCORING SYSTEM:
Irritation grades that ranged from 1 to 10:
grade 1 = no irritation;
2 = least visible capillary injection from the undiluted material;
6 = higher necrosis with the undiluted material;
10 = necrosis from a 0.01% solution
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Irritation score
- Basis:
- other: not further specified
- Time point:
- other: 24 h
- Score:
- 2
- Max. score:
- 10
- Reversibility:
- no data
Any other information on results incl. tables
Irritation on uncovered rabbit belly was reported to be of grade 2 of 10, where Grade 1 indicates no irritation and grade 2 the least visible capillary injection from 10 µl of the undiluted chemical.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
