Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-633-5 | CAS number: 123-51-3
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Remarks:
- Cytotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Drinking “Vodka” or vodka – This is a question
- Author:
- Izabela Rusiecka, Iwona Gągało, Jacek Sein Anand, Daria Schetz, WojciechWaldman
- Year:
- 2 016
- Bibliographic source:
- Toxicology in Vitro 36 (2016) 66–70
Materials and methods
- Principles of method if other than guideline:
- The direct effect of 2M2B on human tissuewas evaluated and compared to that of two other alcohols (ethanol, 3-´methyl-1-butanol)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-methylbutan-1-ol
- EC Number:
- 204-633-5
- EC Name:
- 3-methylbutan-1-ol
- Cas Number:
- 123-51-3
- Molecular formula:
- C5H12O
- IUPAC Name:
- 3-methylbutan-1-ol
- Details on test material:
- Name of the test material (as cited in study report): isoamyl alcohol/3-methyl-1-butanol
Constituent 1
- Specific details on test material used for the study:
- no further details given
Results and discussion
Any other information on results incl. tables
The impact of each alcohol on HEK293 cell survivalwas further confirmed by the calculation of pIC50 and the values are as follows: 2M2B – 1.699, ethanol – 2.025, 3M1B – 0.884.
The results of MTT assay presented here show that the toxicity of 2M2B was comparable to that of ethanol, but lower than that observed after incubation with 3M1B. The drops in cell viability caused by the usage of the former two alcohols did not exceed 20%, and those caused by the latter were within the range of 40–80%.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
