N,N-dimethylisopropylamine

Endpoint summary

Description of key information

Dimethylisopropylamine is harmful by ingestion with an LD50 of 680 mg/kg in rats. A dermal LD0 higher than 200 mg/kg was reported in rabbits for DMIPA and LD0 higher than 2000 mg/kg was reported in rats for the analogue substances, dimethyl-n-propylamine . No relevant acute inhalation toxicity study is available on DMIPA. A 4-h LC50 in rats of 4.499 mg/L for the analogue substance, dimethyl-n-propylamine, allow  to estimatethat DMIPA is toxic by inhalation exposure.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

05. Mar 1975 - 02. Apr 1975

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Scientificially valid study, comparable to guideline, but not according to current standards or GLP.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
A test group consisting of 5 animals/sex was treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Willi Gassner, Sulzfeld, Germany
- Age at study initiation: about 12 weeks
- Weight at study initiation: 162 - 177 g (average weight)
- Fasting period before study: 16 hours
- Housing: 5 per cage
- Diet: Altromin R 1321; Altromin GmbH, Lage/Lippe, Germany, ad libitum
- Water: Fully demineralized water ad libitum each workday; tap water ad libitum on public holidays.
- Acclimation period: at least 8 days


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22-26 °C
- Humidity (%): 45 - 75 %
- Photoperiod (hrs dark / hrs light): 12/12

Route of administration:

oral: gavage

Vehicle:

water

Doses:

316, 464, 681, 825 and 1000 µl/kg bw corresponding to 228, 334, 490, 594 and 720 mg/kg bw; based on a density of 0.72 g/ml at 20°C.

No. of animals per sex per dose:

5

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Frequency of weighing: days 0, 3, 7, 13
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 684 mg/kg bw

Mortality:

720 mg/kg: 1 male died within 24 h and 3 males within 7 days. 3 femaled died within 48 h.
594 mg/kg: 2 males died within 48 h.

Clinical signs:

other: 594 mg/kg and 720 mg/kg bw: dyspnoea, staggering, apathy and abdominal position immediately after application. Dyspnoea, apathy, poor general state and aggressiveness during the following observation days. 490 mg/kg bw: staggering, apathy, slightly incr

Gross pathology:

490 mg/kg bw, 594 mg/kg bw and 720 mg/kg bw:
Heart: acute dilation and congestive hyperemia,
Abdominal cavity: adhesion of organs and peritoneum with the stomach, organized perforation of the stomach in one animal at 1000 mg/kg,
Glandular stomach: diffuse red discoloration with hemorrhagic ulcers, corrosive scar in the stomach,
Intestine: reddish content.

Mortality:

Dose (mg/kg )	Conc.	Gender	1 h	24 h	48 h	day 7	day 14
720	15	male	0/5	1/5	1/5	3/5	3/5
720	15	female	0/5	2/5	3/5	3/5	3/5
594	6	male	0/5	0/5	0/5	0/5	0/5
594	6	female	0/5	2/5	2/5	2/5	2/5
490	6	male	0/5	0/5	0/5	0/5	-
490	6	female	0/5	0/5	0/5	0/5	-
334	6	male	0/5	0/5	0/5	0/5	-
334	6	female	0/5	0/5	0/5	0/5	-
228	3	male	0/5	0/5	0/5	0/5	-
228	3	female	0/5	0/5	0/5	0/5	-

Weight (g):

Dose (mg/kg)	Gender	day 0	day 3	day 7	day 13
720	male	168	154	204	255
594	male	166	137	176	203
490	male	180	180	196	-
334	male	176	219	206	-
228	male	195	182	235	-
720	female	164	156	147	170
594	female	163	159	169	189
490	female	157	170	157	-
334	female	160	177	177	-
228	female	164	149	179	-

Harmful if swallowed. There is indication that the test substance causes local irritation to exposed tissue.

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The LD50 value was 684 mg/kg bw.

Executive summary:

The acute oral toxicity of dimethylisopropylamine was evaluated in a study conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401. A test group consisting of 5 animals/sex was treated at dose levels of 228, 334, 490, 594 and 720 mg/kg bw by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. The LD50 value was 684 mg/kg bw.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

684 mg/kg bw

Quality of whole database:

Scientificially valid study, comparable to guideline, but not according to current standards or GLP.

Acute toxicity: via inhalation route

Link to relevant study records

Reference

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

15 Aug 2011 - 13 Dec 2011

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

2009

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method B.2 (Acute Toxicity (Inhalation))

Version / remarks:

2008

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 870.1300 (Acute inhalation toxicity)

Version / remarks:

1998

Deviations:

no

GLP compliance:

yes

Test type:

standard acute method

Limit test:

no

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Strain as cited in the study report: RccHan:WIST
- Source: Harlan Laboratories B.V., Horst, Netherlands
- Age at study initiation: males, 8 to 9 weeks; females, 10 to 11 weeks
- Mean group weight at study initiation:
- - Males: group 1, 240 g; group 2, 273 g; group 3, 234 g
- - Females: group 1, 182 g; group 2, 186 g; group 3, 188 g
- Housing: Makrolon cages type M III (floor area about 800 cm2) for single housing; Polysulfon cages (floor area about 2065 cm2) for group caging (up to 5 animals/cage) if the animals were free from clinical signs and findings.
- Diet: Kliba-Labordiet (Maus/Ratte Haltung “GLP”; Provimi Kliba SA, Kaiseraugst, Basel, Switzerland), ad libitum
- Water: tap water, ad libitum
- Acclimation period: at least 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Air changes: 15 per hour
- Photoperiod (hrs dark/hrs light): 12/12

Route of administration:

inhalation: vapour

Type of inhalation exposure:

nose/head only

Vehicle:

clean air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE
- A central air conditioning system provided cold air of about 15°C, which was passed through an activated charcoal filter, adjusted to room temperature, and passed again through a second particle filter (H13 (HEPA) Camfil Farr, Germany). The air was compressed (oil-free compressor) by filtering through an inlet air strainer and introducing into the compressor. After passed through an second ultra filter, the compressed, 15 bar air was stored in a storage of 1500 or 5000 L. The compressed air was conducted to the labs via pipes, where the pressure was reduced to 6 bar; in the laboratory, it was then used to generate the inhalation atmospheres.

GENERATION OF TEST ITEM VAPOURS
For each test group the vapours were generated by supplying amounts of the unchanged test substance to a heated vaporizer (glasses with thermostat, 50 °C) by means of a piston metering pump. The vapours that developed were taken up by the supply air and passed into the exposure system.

INHALATION CHAMBER
Head-nose inhalation system INA 60 (glass-steel construction, BASF SE, volume V ˜ 90 L): the animals were restrained in glass tubes and their snouts projected into the inhalation system. The exhaust air was filtered and conducted into the exhaust air of the building. The exposure system was located inside an exhaust cabin in an air-conditioned laboratory. During each exposure, the following parameters were recorded four times at about 1-hour intervals: continuous measurement of compressed air flow supply, with adjustment; continuous measurement of exhaust air flow, with adjustment. The lower amounts of exhaust air, which were adjusted by means of a separate exhaust air system, achieved positive pressures inside the exposure systems. This ensured that the mixtures of test substance and air were not diluted with laboratory air in the breathing zones of the animals.

TEST ATMOSPHERE ANALYSIS
The nominal concentrations of the test item vapours were calculated from the amounts of test item dosed and the supply air flows.
For determination of the concentration of the test item in the inhalation atmosphere, the test atmosphere sample volumes were adjusted to achieve suitable amounts of the test item in the samples of the test groups in reference to the calibration of the analytical method. 2-Propanol was used as sorption solvent and was contained in 3 absorption vessels connected in series. The contents of the first 2 vessels were pooled and analyzed for each sample; the third vessel was used to control the effectiveness of the sorption for all samples of the atmosphere and was analyzed separately at the end of the sampling campaign. Sampling was done immediately adjacent to the animals' noses at a separate spare port.
Sampling flow was 1 L/minute and sampling frequency was 4 at hourly intervals.

OXYGEN, TEMPERATURE AND HUMIDITY MONITORING
Since the air change (at least 33 times/hour, calculated by dividing the supply air flows by the volume of the inhalation chamber) was judged to be sufficient to prevent oxygen depletion by the breathing of the animals, no monitoring of oxygen content was done. The temperature in the inhalation chambers was measured continuously. The humidity in the inhalation chambers was measured with a dielectric probe.

Analytical verification of test atmosphere concentrations:

yes

Remarks:

Analysis was done by gas chromatography (for details, see above)

Duration of exposure:

4 h

Concentrations:

measured: 0.479 (test group 1), 2.303 (test group 2) and 5.073 (test group 3) mg/L air

No. of animals per sex per dose:

Five

Control animals:

no

Details on study design:

DURATION OF OBSERVATION PERIOD
14 days
FREQUENCY OF OBSERVATIONS FOR MOTALITY AND CLINICAL SYMPTOMS
A check for any dead or moribund animal was made twice each workday and once on Saturdays, Sundays and on public holidays. Detailed clinical observations were recorded for each animal separately several times during exposure and at least once daily on the pre-exposure day and during the observation period.
FREQUENCY OF WEIGHING
Individual body weights were recorded once during the acclimatization period, shortly before exposure (day 0) and at least on days 1, 3 and 7, and before the sacrifice of the animals at the end of the observation period.
NECROPSY
At the end of the observation period the surviving animals were sacrificed with CO2-inhalation and were subjected to gross pathological examination as well as the animal which died before.

Statistics:

The LC50 was calculated by Probit analysis (Finney DJ, "Probit Analysis" Cambridge University Press, 1971); for results of the type ”LC50 greater than”, ”LC50 approx.”, or ”LC50 smaller than”, the binomial test was used for statistical evaluation (Steel RGD and Torrie JH, Principles and procedures of statistics a biometrical approach. McGraw - Hill, 1984)

Sex:

male/female

Dose descriptor:

LC50

Effect level:

4.499 mg/L air (analytical)

Based on:

test mat.

Exp. duration:

4 h

Remarks on result:

other: 0% mortality at 0.479 mg/L, 0% mortality at 2.303 mg/L, 90% mortality at 5.073 mg/L

Mortality:

No mortality occurred at the tested concentrations of 0.479 and 2.303 mg/L air.
At 5.073 mg/L air, 4/5 males and 5/5 females died during and after exposure (day 0), resulting in 90% mortality at the highest concentration level tested in this study.

Clinical signs:

other: Clinical signs of toxicity in animals exposed to 0.479 mg/L comprised piloerection and substance contaminated fur. These various findings were observed after exposure on study day 0. No clinical signs and findings were observed from study day 1 onwards.

Body weight:

The mean body weights of the animals exposed to 0.479 mg/L decreased during the first post exposure observations day and increased from study day 3 onward.
The mean body weights of the animals exposed to 2.303 mg/L decreased during the first post exposure observations day and increased from study day 3 onward.
In the 5.073 mg/L group, the body weight of the male animal surviving the exposure period decreased during the first post exposure observations day and increased from study day 3 onward.

Gross pathology:

In animals exposed to 0.479 mg/L, necropsy revealed no gross pathological abnormalities.
In animals exposed to 2.303 mg/L, necropsy revealed no gross pathological abnormalities.
In animals exposed to 5.073 mg/L, necropsy of those animals that died (4 males, 5 females) revealed edema of the lung in only one female; necropsy of the remaining animals as well as of the male survivor revealed no gross pathological abnormalities.

Analytical monitoring of temperature and humidity:

Test Group	Mean Temperature (°C)	Mean relative humidity (%)
Group 1, 0.479 mg/L	28.0 ± 0.9*	55.3 ± 5.0
Group 2, 2.303 mg/L	23.1 ± 0.2	54.1 ± 2.1
Group 3, 5.073 mg/L	23.8 ± 0.3	67.8 ± 0.4
*, The mean temperature above the range given in the guidelines resulted from the technical need to use high generation temperature to reach the desired concentrations.

Interpretation of results:

Category 3 based on GHS criteria

Conclusions:

CLP: Acute Inhalation Category 3, H331

Executive summary:

Dimethyl-n-propylamine was investigated for acute inhalation toxicity in a study conducted with Wistar rats according to the OECD TG 403 (2009). The study conduct followed GLP. Groups of five male and five female rats were head - nose exposed during 4 hours to following measured concentrations of the test item vapour: 0.479, 2.303 and 5.073 mg/L air. In fact, the animals were exposed to the inhalation atmosphere for 4 hours plus equilibration time of the inhalation systems (t99 minimum 4 min).

Whereas no mortality was observed at the 2 lowest tested concentrations of 0.479 and 2.303 mg/L air, 90% mortality (4/5 males, 5/5 females) was reached at the highest test concentration of 5.073 mg/L air during and shortly after exposure. Clinical signs were observed in all 3 groups, lasting for up to 1 day following exposure; these signs comprised e.g., piloerection, substance contaminated fur, accelerated respiration, labored and intermittent respiration, abdominal respiration, red encrusted nose. The mean body weights of the animals decreased during the first post exposure observations day and increased from study day 3 onward. Necropsy was inconspicuous, except for one died female showing lung edema. The LC50 for male and female rats was estimated to be 4.5 mg/L air.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LC50

Value:

4 499 mg/m³ air

Quality of whole database:

GLP guideline study

Acute toxicity: via dermal route

Link to relevant study records

Reference

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1999

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Version / remarks:

1984

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method B.3 (Acute Toxicity (Dermal))

Version / remarks:

1992

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 870.1200 (Acute Dermal Toxicity)

Version / remarks:

1998

Deviations:

no

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Strain as cited in study report: chbb: thom (SPF)
- Source: Boehringer Ingelheim Pharma KG
- Age at study initiation: young adult animals
- Weight at study initiation: 200-300 g
- Housing: single housing in stainless steel wire mesh cages, type DK-III (Becker & Co., Castrop-Rauxel, FRG)
- Diet: Kliba-Labordiet (Provimi Kliba SA, Kaiseraugst, Switzerland), ad libitum
- Water: tap water, ad libitum
- Acclimation period: at least 1 week

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark/hrs light): 12/12

Type of coverage:

semiocclusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Area of exposure: 50 cm2
- % coverage: 10
- Type of wrap if used: semi-occlusive dressing consisting of four layers absorbent gauze and Fixomull stretch (adhesive fleece)
- Fur was clipped 24 hrs before study begin

REMOVAL OF TEST SUBSTANCE
- Washing: after removal of the dressing, the application site was rinsed with warm water
- Time after start of exposure: 24 hours

TEST MATERIAL
- Application volume: 2.78 mL/kg bw
- Density: 0.719 g/mL

Duration of exposure:

24 hours

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

DURATION OF OBSERVATION PERIOD
14 days
FREQUENCY OF OBSERVATIONS FOR MOTALITY AND CLINICAL SYMPTOMS
A check for any dead or moribund animal was made twice each workday and once on Saturdays, Sundays and on public holidays. Clinical symptoms were recorded several times on the day of administration and at least once per workday thereafter.
FREQUENCY OF WEIGHING
Individual body weights were recorded shortly before exposure (day 0), weekly thereafter, and finally before the sacrifice of the animals at the end of the observation period.
SKIN FINDINGS
Individual examination of skin was done between 3 to 60 minutes after removal of the dressing (i.e., day 1), weekly thereafter, and at the end of the observation period. The findings were scored according to the Draize scoring system (Draize, JH, Appraisal of the safety of chemicals in foods, drugs and cosmetics. The association of food and drug officials of the United States Austin,Texas, 1959).
NECROPSY
At the end of the observation period the surviving animals were sacrificed with CO2-inhalation and were subjected to gross pathological examination as well as the animal which died before.

Statistics:

The binomial test (Snedecor GW and Cochran WG, Statistical methods, 8th ed., Iowa State University Press/Ames, 1989) was used.

Sex:

male/female

Dose descriptor:

LD0

Effect level:

>= 2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: No mortality, symptoms, local effects

Mortality:

no mortality occurred.

Clinical signs:

other: Neither clinical symptoms of toxicity nor local skin reactions could be evidenced.

Gross pathology:

At necropsy, gross pathology revealed no abnormalities.

Body weight data:

Animals		Individual body weights (g)
Sex	Number	Day 0	Day 7	Day 13
Males	1	279	304	333
	2	276	296	322
	3	280	308	346
	4	276	298	328
	5	276	301	329
Females	1	229	219	226
	2	229	241	248
	3	230	225	250
	4	227	224	241
	5	234	234	240

 

Interpretation of results:

GHS criteria not met

Executive summary:

Dimethylpropylamine was tested for acute dermal toxicity in rats in a limit test conducted according to the OECD TG 402 (1987). The study conduct was GLP conform. The test item was applied at 2000 mg/kg bw onto the clipped skin of each of 5 male and 5 female animals, under semi-occlusive conditions for 24 hours.

Neither mortality nor clinical symptoms of toxicity were observed. No skin reactions were noticed. Body weights and body weight gain were as expected, and at necropsy, gross pathology revealed no abnormalities. Therefore the LD0 for acute dermal toxicity was > 2000 mg/kg bw for male and female rats.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

discriminating dose

Value:

2 000 mg/kg bw

Quality of whole database:

GLP guideline study

Additional information

Acute oral toxicity

The acute oral toxicity of dimethylisopropylamine was evaluated in a study conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401 (BASF 1975). A test group consisting of 5 animals/sex was treated at dose levels of 228, 334, 490, 594 and 720 mg/kg bw by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy. The LD50 value was 684 mg/kg bw.

The Acute oral toxicity of dimethylisopropylamine (DMIPA) was evaluated in male and female mice according to a protocol similar to the OECD N°401 guideline (Truhaut, 1079). Groups of 10 or 20 mice were administered DMIPA at dose levels of 500, 625, 750, 1000, 1125, 1250 and 1500 mg/kg. 9/20 males and 10/20 females died when treated at 1000 mg/kg. All female died in less than 48hours after administration of 1125 mg/kg and 17/20 male died after administration of 1250 mg/kg. The oral LD50 of DMIPA in mice is 975+/-50 mg/kg in male and 750+/-40 mg/kg in female.

 

Acute dermal toxicity

 

A dermal LD0 higher than 200 mg/kg in rabbits was reported in a BASF's study (1975) with dimethylisopropylamine.

However the analogue substance, dimethyl-n-propylamine, was tested for acute dermal toxicity in rats in a limit test conducted according to the OECD TG 402 (1987) (BASF, 2000). The study conduct was GLP conform. The test item was applied at 2000 mg/kg bw onto the clipped skin of each of 5 male and 5 female animals, under semi-occlusive conditions for 24 hours. Neither mortality nor clinical symptoms of toxicity were observed. No skin reactions were noticed. Body weights and body weight gain were as expected, and at necropsy, gross pathology revealed no abnormalities. Therefore the LD0 for acute dermal toxicity was > 2000 mg/kg bw for male and female rats.

 

Acute inhalation toxicity

No relevant acute inhalation toxicity study is available on DMIPA. A study available on an analogue substance, dimethyl-n-propylamine, allow to estimate the acute inhalation toxicity of DMIPA.

Dimethyl-n-propylamine was investigated for acute inhalation toxicity in a study conducted with Wistar rats according to the OECD TG 403 (BASF SE, 2012). The study conduct followed GLP. Groups of five male and five female rats were head - nose exposed during 4 hours to following measured concentrations of the test item vapour: 0.479, 2.303 and 5.073 mg/L air. In fact, the animals were exposed to the inhalation atmosphere for 4 hours plus equilibration time of the inhalation systems (t99 minimum 4 min). Whereas no mortality was observed at the 2 lowest tested concentrations of 0.479 and 2.303 mg/L air, 90% mortality (4/5 males, 5/5 females) was reached at the highest test concentration of 5.073 mg/L air during and shortly after exposure. Clinical signs were observed in all 3 groups, lasting for up to 1 day following exposure; these signs comprised e.g., piloerection, substance contaminated fur, accelerated respiration, labored and intermittent respiration, abdominal respiration, red encrusted nose. The mean body weights of the animals decreased during the first post exposure observations day and increased from study day 3 onward. Necropsy was inconspicuous, except for one died female showing lung edema. The LC50 for male and female rats was estimated to be 4.5 mg/L air;

This read-across is supported by the acute inhalation data from BASF and Truhaut (1979) on DMIPA.

Justification for selection of acute toxicity – oral endpoint
Key study

Justification for selection of acute toxicity – inhalation endpoint
No reliable data on DMIPA. Read across to Dimethyl-n-propylamine

Justification for selection of acute toxicity – dermal endpoint
Read across to Dimethyl-n-propylamine

Justification for classification or non-classification

Acute oral toxicity:

The oral LD₅₀ of DMIPA was 684 mg/kg in rats. In accordance with Regulation (EC) No 1272/2008, DMIPA shall be classified as Acute Tox. 4 (Hazard statement: H302; Harmful if swallowed).

Acute inhalation toxicity:

The LC₅₀ of dimethyl-n-propylamine, an analogue substance to DMIPA, was 4.5 mg/L. On this basis and in accordance with Regulation (EC) No 1272/2008 DMIPA shall be classified as Acute Tox. 3 (Hazard statement: H331; Toxic if inhaled).

Acute dermal toxicity:

The percutaneous LD₀ of the analogue substance, dimethyl-n-propylamine, was greater than 2000 mg/kg in rats.On this basis and in accordance with Regulation (EC) No 1272/2008 , no classification is warranted for DMIPA.