N,N-dimethylisopropylamine

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

BASF-Test:
Young adult laboratory mice were purchased from breeder. Several groups of 5 mice per sex and dose are treated simultaneously with preparations of the test substance in a suitable vehicle. The substance is injected into the peritoneal cavity. The concentrations of the preparations were used to achieve comparable volumes per kg body weight. Group-wise documentation of clinical signs is performed during the study period of 7 days.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

N,N-dimethylisopropylamine

EC Number:

213-635-5

EC Name:

N,N-dimethylisopropylamine

Cas Number:

996-35-0

Molecular formula:

C5H13N

IUPAC Name:

dimethyl(propan-2-yl)amine

Details on test material:

- Name of test material (as cited in study report): N, N-Dimethylisopropylamin
- Purity: 99%

Test animals

Species:

mouse

Strain:

NMRI

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Ivanovas
- Mean weight at study initiation: 23.9 g (females), 27.7 g (males)
no further data available

ENVIRONMENTAL CONDITIONS
no data

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

water

Doses:

100, 147, 215, 316, 464 and 681 µL/kg bw (=> 72, 106, 155, 228, 334 and 490 mg/kg bw, based on a density of 0.72 g/cm³)

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 8 days
- Frequency of observations and weighing: animals were observed for mortality and clinical signs 1, 24 and 48 h and 8 days after application; weighing was done at study initiation and on day 2 and 8 (surviving animals)
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 100 mg/kg bw

Based on:

test mat.

95% CL:

> 72 - < 106

Mortality:

- 72 mg/kg bw: 1/10 (1 animal died within 48 h)
- 106 mg/kg bw: 6/10 (1 animal died within 48 h and 5 within the first week)
- 155 mg/kg bw: 10/10 (4 animals died within 24 h, 2 within the second day and 4 within the first week after application)
- 334 and 228 mg/kg bw: 20/20 (all animals died within 24 h after application)
- 490 mg/kg bw: 10/10 (7 animals died within the first hour after application, 3 within 24 h)

Clinical signs:

Dyspnoea, apathy, tremor, poor general state, spastical gait, abdominal position, convulsions