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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: JO RF 5 Avril 1971
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N-dimethylisopropylamine
EC Number:
213-635-5
EC Name:
N,N-dimethylisopropylamine
Cas Number:
996-35-0
Molecular formula:
C5H13N
IUPAC Name:
dimethyl(propan-2-yl)amine
Constituent 2
Reference substance name:
N,N dimethylpropan 2 amine
IUPAC Name:
N,N dimethylpropan 2 amine
Details on test material:
- Name of test material (as cited in study report): Dimethylisopropyamine
- Physical state: liquid
- Analytical purity: 94-96%
- Impurities (identity and concentrations): no data
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: no data
- Other: origin: BASF Ludwigshafen

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: no data
- Housing:no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum):no data
- Acclimation period:no data


ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr):no data
- Photoperiod (hrs dark / hrs light):no data


IN-LIFE DATES: From: To:no data

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
Amount applied: 0.1 ml
Duration of treatment / exposure:
not rinsed
Observation period (in vivo):
24h, 48h, 72h, 96h, 7days
Number of animals or in vitro replicates:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24, 48 and 72h
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks:
after 7 days
Irritation parameter:
iris score
Time point:
other: 24, 48 and 72h
Reversibility:
not reversible
Remarks:
after 7 days
Remarks on result:
other: not scoreable
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24, 48 and 72h
Score:
3
Max. score:
3
Reversibility:
not reversible
Remarks:
after 7 days
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 24, 48 and 72h
Score:
2.8
Max. score:
4
Reversibility:
not reversible
Remarks:
after 7 days
Irritant / corrosive response data:
severe iris opacification

Any other information on results incl. tables

Reading

 

Rabbit

Mean

1

2

3

4

5

6

24hours

Cornea

4

4

4

4

4

4

95.3/100

4

4

4

4

4

4

Iris

-

-

-

-

-

-

Conjunctive

3

3

3

3

3

3

1

1

2

2

2

2

3

3

3

3

3

3

 

48hours

Cornea

4

4

4

4

4

4

95.3/100

4

4

4

4

4

4

Iris

-

-

-

-

-

-

Conjunctive

3

3

3

3

3

3

1

1

2

2

2

2

3

3

3

3

3

3

 

72hours

Cornea

4

4

4

4

4

4

93.3/100

4

4

4

4

4

4

Iris

-

-

-

-

-

-

Conjunctive

3

3

3

3

3

3

1

1

1

1

1

2

2

2

2

3

3

3

 

96hours

Cornea

4

4

4

4

4

4

95.3/100

4

4

4

4

4

4

Iris

-

-

-

-

-

-

Conjunctive

3

3

3

3

3

3

1

2

2

2

2

2

2

3

3

3

3

3

 

7days

Cornea

4

4

4

4

4

4

98.3/100

4

4

4

4

4

4

Iris

-

-

-

-

-

-

Conjunctive

3

3

3

3

3

3

1

4

4

4

4

4

1

3

3

3

3

3

 

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye) based on GHS criteria
Conclusions:
Under these experimental conditions, DMIPA has to be classified as corrosive.
Executive summary:

The acute eye irritation of Dimethylisopropylamine (DMIPA) was evaluated in rabbits according to the “Journal Officiel Français arrêté du 05 avril 1971”. 0,1mL of DMIPA was applied in the right eye of 6rabbits and the reaction was observed 24, 48, 72, 96hours and 7days after administration.

Iris has never been examined because of the total corneal opacity from 24hours. Maximal scores are recorded until the day7.

Under these experimental conditions, DMIPA has to be classified as corrosive.