resorcinol; 1,3-benzenediol

Repeated dose toxicity: inhalation

Administrative data

Endpoint:

short-term repeated dose toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Provides basic data for initial dose selection in the 90 day study.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: standard repeated dose

Principles of method if other than guideline:

Method: other

GLP compliance:

not specified

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Resorcinol

EC Number:

203-585-2

EC Name:

Resorcinol

Cas Number:

108-46-3

Molecular formula:

C6H6O2

IUPAC Name:

resorcinol

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

not specified

Duration of treatment / exposure:

14 days

Frequency of treatment:

8 hrs/day

Doses / concentrations

Remarks:

Doses / Concentrations:
220 ppm
Basis:

Details on study design:

A preliminary 14 day inhalation exposure was conducted on 10 rats, five males and five females, to detemine the feasibility of the 220 ppm  concentration for the 90 day study.  At the end of the exposure, all animals were sacrificed and examined grossly.

Results and discussion

Results of examinations

Details on results:

Except for slight hemorrhagic spotting on the lungs of one male rat, all tissues appeared essentially normal.  No tissues of animals in this group were examined histopathologically.  On the basis of this pilot study, it was concluded that the 220 ppm concentration was appropriate for the 90 day study

Effect levels

Dose descriptor:

other: Determination of definitive study concentration

Effect level:

220 ppm

Based on:

test mat.

Sex:

male/female

Target system / organ toxicity

Critical effects observed:

not specified

Applicant's summary and conclusion

Conclusions:

A 14 day range finding study in 5 male and female Wistar rats (exposed to 220 ppm for 8 hrs/day) was conducted to determine appropriate concentrations for a subsequent 90 day study. At 220 ppm only one male rat had slight hemorrhagic spotting on the lungs while the remaining tissues appeared normal. No tissues of animals in this group were examined histopathologically. The subsequent 90 day study was considered invalid as it does not meet the requirements of current guidelines.