Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-585-2 | CAS number: 108-46-3
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Remarks:
- in vivo antithyroid activity in rats
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No additional details available. Included due to prior inclusion in SIAR.
Data source
Reference
- Reference Type:
- publication
- Title:
- Humic substances, a possible source of environmental goitrogens.
- Author:
- Cooksey, R.C., Gaitan, E., Lindsay, R.F., Hill, H.B., Kelly, K.
- Year:
- 1 985
- Bibliographic source:
- Organic Geochemistry 8:77-80.
Materials and methods
- Type of study / information:
- Type: other: In vivo, antithyroid activity
Test guideline
- Qualifier:
- no guideline required
Test material
- Reference substance name:
- Resorcinol
- EC Number:
- 203-585-2
- EC Name:
- Resorcinol
- Cas Number:
- 108-46-3
- Molecular formula:
- C6H6O2
- IUPAC Name:
- resorcinol
Constituent 1
Results and discussion
Any other information on results incl. tables
Resorcinol exhibited goitrogenic as well as antithyroid effects in vivo in the rat. When compared with the controls, resorcinol treated rats had significantly larger thyroid glands and decreased the ability of their thyroids to incorporate 125I into the active thyroid hormones, triiodothyronine (T3) and thyroxine (T4) as indicated by higher I/T3and T4 ratio and lower T3and T4 concentrations.
Applicant's summary and conclusion
- Conclusions:
- Female rats of Wistar Crl:(WI) BR strain weighing 95-105 g were divided into groups of 5 rats each and fed on a low iodine low protein shredded wheat diet for the duration of the experiment, lasting 30 days. Control rats were given goitrogen-free water while experimental rats received daily 9 umol of resorcinol in their water.
Resorcinol exhibited goitrogenic as well as antithyroid effects in vivo in the rat. When compared with the controls, resorcinol treated rats had significantly larger thyroid glands and decreased the ability of their thyroids to incorporate 125I into the active thyroid hormones, triiodothyronine (T3) and thyroxine (T4) as indicated by higher I/T3and T4 ratio and lower T3and T4 concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
