Registration Dossier
Registration Dossier
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EC number: 203-585-2 | CAS number: 108-46-3
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Following Draft OECD Early life stage guidelines, results for Danio rerio, included a 7 day EC50 (total embryotoxicity (lethality and malformations)) = 54.8 mg/L (nominal), 7 day LC50 = 262 mg/L (nominal), 7 day LOEC (mortality): 320 mg/L (nominal) and 7 day LOEC (Total embryotoxicity): 100 mg/L (nominal) (Van Leeuven et al., 1990).
Several chronic studies are available in fish and aquatic invertebrates. Following Draft OECD Early life stage guidelines, results for the 60 day study in Salmo gairdneri indicate the EC50 (Total embryotoxicity (lethality and malformations) was = 260 mg/L, 60 day LOEC (mortality): 320 mg/L, 60 day LOEC (total embryotoxicity): 320 mg/L, 60 day LOEC (length): 100 mg/L and 60 day LOEC (weight): 32 mg/L (Van Leeuven et al., 1990).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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