Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-585-2 | CAS number: 108-46-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Provides basic data
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The benzenediols: catechol, resorcinol and hydroquinone - a review of the industrial toxicology and current industrial exposure limits.
- Author:
- Flickinger, C.W.
- Year:
- 1 976
- Bibliographic source:
- American Industrial Hygiene Association Journal, 37:596-606.
- Report date:
- 1976
- Reference Type:
- other: Internal Document
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Resorcinol
- EC Number:
- 203-585-2
- EC Name:
- Resorcinol
- Cas Number:
- 108-46-3
- Molecular formula:
- C6H6O2
- IUPAC Name:
- resorcinol
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Harlan-Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- other:
- Duration of exposure:
- 1 h
- Concentrations:
- At the 1 hour time interval, rats were exposed to concentrations of 7800 mg/m3 (57.4% weight/unit volume)(1732 ppm) and 2130 mg/mg3 (18.2% weight/unit volume) (473 ppm). It should be noted that in the study conducted at a concentration of 7800 mg/m3, the solution turned milky. And some precipitate was noted. It is likely that flow concentrations were less than the concentration indicated.
- No. of animals per sex per dose:
- 12 (6 rats per dose)
- Details on study design:
- The acute toxic effects of catechol-, resorcinol- and phenol-water aerosols were investigated at comparable airborne concentrations.
Samples were dissolved in distilled water and the resulting solutions were aerosolized using a D18 Dautrebande aerosol generator operated at 30 psi. At this operating pressure, the D18 generator delivered droplets of 1µ or smaller. The concentration of the sample solutions was adjusted so that the airbourne concentration approximated 2,000 mg/m3 (444 ppm) of the sample in air. Airborne concentrations were determined by measurement of the volume loss of solution following aerosolization. The weight of sample present in that volume was then calculated and related to the total volume of air in generating the aerosol to obtain chamber concentrations. In groups of 6, rats, weighing between 87 and 126 g, were subjected to a single 1 hour inhalation period of the aerosolized sample.
At the 1 hour time interval, rats were exposed to concentrations of 7800 mg/m3 (57.4% weight/unit volume)(1732 ppm) and 2130 mg/mg3 (18.2% weight/unit volume) (473 ppm). It should be noted that in the study conducted at a concentration of 7800 mg/m3, the solution turned milky. And some precipitate was noted. It is likely that flow concentrations were less than the concentration indicated.
The animals were held for 14 days following exposure and were then weighed and sacrificed for gross necropsy.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LC0
- Effect level:
- > 7 800 mg/m³ air
- Exp. duration:
- 1 h
- Mortality:
- No deaths resulted when rats inhaled resorcinol-water aerosols for one-hour at concentrations of 2,130 mg/M3 (473 ppm) and approx 7,800 mg/M3 (1732 ppm) for a 1 hour period.
- Body weight:
- All animals had normal 14-day weight gains.
- Gross pathology:
- No lesions attributable to inhalation of the aerosol were seen at gross necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- The use of the study for classification is limited as exposure is for only 1 hour.
- Conclusions:
- No toxic effects are anticipated from acute exposures to resorcinol at aerosol concentrations approximating 7,800 mg/m3 (1732 ppm) for one hour.The classification is limited by the highest concentration tested (1732 ppm), which dictates a classification of Toxicity Category III in accordance with EC 1272/2008 CLP..
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.