Registration Dossier
Registration Dossier
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EC number: 231-868-0 | CAS number: 7772-99-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study, according guideline
Data source
Reference
- Reference Type:
- other: summary of study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tin dichloride
- EC Number:
- 231-868-0
- EC Name:
- Tin dichloride
- Cas Number:
- 7772-99-8
- Molecular formula:
- [Cl-].[Cl-].[Sn++]
- IUPAC Name:
- tin dichloride
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Controls:
- not specified
- Duration of treatment / exposure:
- 3min, 1h, 4 h
- Observation period:
- 24, 48, 72 h, 14d
- Number of animals:
- 4h: 1 male
1h: 3 male
3 min: 3 male
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1, 24, 48, 72h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- no data
- Remarks on result:
- other: 4 hour exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1, 24, 48, 72h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- other: 1 hour exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1, 24, 48, 72h
- Score:
- 0
- Max. score:
- 1
- Reversibility:
- not fully reversible within: 14 d
- Remarks on result:
- other: 3 minutes exposure
- Other effects:
- The test mateial was classified as corroxice to rabbit scin
Applicant's summary and conclusion
- Interpretation of results:
- other: corrosive R34
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The test material was classified as corrosive to rabbit skin
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