Registration Dossier
Registration Dossier
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EC number: 231-868-0 | CAS number: 7772-99-8
Toxicity to reproduction
Administrative data
- Endpoint:
- three-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no glp, equvalent or similar to giudeline
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Tin and stannous chloride
- Author:
- WHO
- Year:
- 1 982
- Bibliographic source:
- WHO Food Additives Series 17
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 416 (Two-Generation Reproduction Toxicity Study)
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tin dichloride
- EC Number:
- 231-868-0
- EC Name:
- Tin dichloride
- Cas Number:
- 7772-99-8
- Molecular formula:
- [Cl-].[Cl-].[Sn++]
- IUPAC Name:
- tin dichloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CPB: WU randomly bred
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- no data
- Frequency of treatment:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 200, 400, 800 ppm
Basis:
other: Sn in diet
- No. of animals per sex per dose:
- no data
- Control animals:
- yes
Results and discussion
Results: F2 generation
Effect levels (F2)
- Dose descriptor:
- NOEL
- Generation:
- F2b
- Effect level:
- > 800 ppm
- Sex:
- not specified
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- No teratogenic effects. The growth of the parent rats was not adversely affected in any
generation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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