Registration Dossier
Registration Dossier
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EC number: 231-868-0 | CAS number: 7772-99-8
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: no glp, only similar to guideline
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- short-term toxicity studies on some salts and oxides of tin in rats
- Author:
- de Groot
- Year:
- 1 973
- Bibliographic source:
- Fd. Comsmet. Toxicol Vol. 11, pp, 19-30
- Report date:
- 1972
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)
- Deviations:
- not specified
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Tin dichloride
- EC Number:
- 231-868-0
- EC Name:
- Tin dichloride
- Cas Number:
- 7772-99-8
- Molecular formula:
- [Cl-].[Cl-].[Sn++]
- IUPAC Name:
- tin dichloride
- Test material form:
- not specified
- Details on test material:
- SnCl_2 * 2aq
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 4 and 13 weeks
- Frequency of treatment:
- daily with diet
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.00, 0.03, 0.10, 0.30, 1.00 % Sn in diet
Basis:
nominal in diet
- No. of animals per sex per dose:
- 10 animals per sex per dose per timeframe.
- Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- > 22 - < 33 other: mg Sn /kg bw day
- Based on:
- element
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Severe growth retardation,
decreased food efficiency, slight anaemia and slight histological changes in the liver were
observed with 0.3 70 or more of stannous sulphate.
As NOAL a value of 22-33 mg Sn/kg bw day was determined, no LOAEL was fouind.
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