Registration Dossier
Registration Dossier
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EC number: 231-868-0 | CAS number: 7772-99-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study before guideline and glp time
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- dose selection
- Principles of method if other than guideline:
- study from 1975, comparable with OECD 423; dose selection see point doses
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- stannous chloride dihydrate
- IUPAC Name:
- stannous chloride dihydrate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- fasted (no food 16-18hrs before application): 600, 1200, 1800, 2400, 4800 mg/kg bw
feed: 1500, 1800, 3000, 6000 mg / kg /bw - No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 274.6 mg/kg bw
- Based on:
- other: SnCl_2 * H2O
- 95% CL:
- > 1 613.2 - < 3 207.2
- Remarks on result:
- other: fasted rats
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 190.1 mg/kg bw
- Based on:
- other: SnCl_2 *H2O
- 95% CL:
- > 2 044.9 - < 4 976.6
- Remarks on result:
- other: feeded tats
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 for stannous dichloride dihydrate was determined to be 2274.6 mg/kg bw. Form this value the LD50 for stannous chloride form 1910.1 mg/kg bw was calculated.
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