Registration Dossier
Registration Dossier
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EC number: 231-868-0 | CAS number: 7772-99-8
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study before guideline and glp time
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- dose selection
- Principles of method if other than guideline:
- study from 1975, comparable with OECD 423; dose selection see point doses
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- fasted (no food 16-18hrs before application): 600, 1200, 1800, 2400, 4800 mg/kg bw
feed: 1500, 1800, 3000, 6000 mg / kg /bw - No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 274.6 mg/kg bw
- Based on:
- other: SnCl_2 * H2O
- 95% CL:
- > 1 613.2 - < 3 207.2
- Remarks on result:
- other: fasted rats
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 3 190.1 mg/kg bw
- Based on:
- other: SnCl_2 *H2O
- 95% CL:
- > 2 044.9 - < 4 976.6
- Remarks on result:
- other: feeded tats
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 for stannous dichloride dihydrate was determined to be 2274.6 mg/kg bw. Form this value the LD50 for stannous chloride form 1910.1 mg/kg bw was calculated.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 910 mg/kg bw
- Quality of whole database:
- -
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2011/2012
- Reliability:
- 1 (reliable without restriction)
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: HsdHan:WIST strain
- Sex:
- male/female
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5, 1, 0.5 mg/L
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 2 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: calculated LC50 in accordiance with OECD 436
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material was classified as Category 4 in respect of its acute inhalation toxicity according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 1.5 mg/m³ air
- Quality of whole database:
- -
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
-
Justification for selection of acute toxicity – oral endpoint
value for SnCl_2
Justification for selection of acute toxicity – inhalation endpoint
onlx vlaue for the Sn(II) oxalate available, no study in the Sn(II)chloride in due of animal protection (corrosive / irritation properties of the test material),, maxiumum concentration in air 1.1 mg/m³
Calculation of the ATE for SnCl_2 form Sn(II) oxalate according guidelines
Justification for classification or non-classification
see endpoints, 1272/2008/EC
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