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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1971
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: early study report, essential details given

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report date:
1971

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Hex-3-yne-2,5-diol
EC Number:
221-209-5
EC Name:
Hex-3-yne-2,5-diol
Cas Number:
3031-66-1
Molecular formula:
C6H10O2
IUPAC Name:
hex-3-yne-2,5-diol

Test animals / tissue source

Species:
rabbit
Strain:
Vienna White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: untreated eye of the same animal
Amount / concentration applied:
50 mg
Duration of treatment / exposure:
single exposure
Observation period (in vivo):
8 days
Number of animals or in vitro replicates:
2
Details on study design:
SCORING SYSTEM: BASF internal standard. Scores were transfered to Draize Scoring System

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
animal #1
Time point:
other: 24/48/72h
Score:
ca. 3
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: Staphyloma
Irritation parameter:
cornea opacity score
Basis:
animal #2
Time point:
other: 24/48/72h
Score:
ca. 3
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: Staphyloma
Irritation parameter:
conjunctivae score
Basis:
animal #1
Time point:
other: 24/48/72h
Score:
ca. 2
Max. score:
4
Reversibility:
not reversible
Irritation parameter:
conjunctivae score
Basis:
animal #2
Time point:
other: 24/48/72h
Score:
ca. 2
Max. score:
4
Reversibility:
not reversible
Irritation parameter:
chemosis score
Basis:
animal #1
Time point:
other: 24/48/72h
Score:
ca. 2
Max. score:
4
Reversibility:
not reversible
Irritation parameter:
chemosis score
Basis:
animal #2
Time point:
other: 24/48/72h
Score:
ca. 2
Max. score:
4
Reversibility:
not reversible
Irritation parameter:
iris score
Basis:
animal #1
Time point:
other: 24/48/72h
Score:
ca. 2
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: bleedings
Irritation parameter:
iris score
Basis:
animal #2
Time point:
other: 24/48/72h
Score:
ca. 2
Max. score:
4
Reversibility:
not reversible

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye)
Remarks:
Migrated information