Registration Dossier
Registration Dossier
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EC number: 221-209-5 | CAS number: 3031-66-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: early study report, essential details given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- Hex-3-yne-2,5-diol
- EC Number:
- 221-209-5
- EC Name:
- Hex-3-yne-2,5-diol
- Cas Number:
- 3031-66-1
- Molecular formula:
- C6H10O2
- IUPAC Name:
- hex-3-yne-2,5-diol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of the same animal
- Amount / concentration applied:
- 50 mg
- Duration of treatment / exposure:
- single exposure
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- SCORING SYSTEM: BASF internal standard. Scores were transfered to Draize Scoring System
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 24/48/72h
- Score:
- ca. 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Staphyloma
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- other: 24/48/72h
- Score:
- ca. 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Staphyloma
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24/48/72h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 24/48/72h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 24/48/72h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: 24/48/72h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 24/48/72h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: bleedings
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- other: 24/48/72h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not reversible
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information
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