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EC number: 221-209-5 | CAS number: 3031-66-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: early study report, essential details given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- Hex-3-yne-2,5-diol
- EC Number:
- 221-209-5
- EC Name:
- Hex-3-yne-2,5-diol
- Cas Number:
- 3031-66-1
- Molecular formula:
- C6H10O2
- IUPAC Name:
- hex-3-yne-2,5-diol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- unchanged solidified test substance
- Duration of treatment / exposure:
- single exposure
- Observation period:
- 24 h, 8 days
- Number of animals:
- 2
- Details on study design:
- SCORING SYSTEM: BASF internal standard. Scores were transfered to Draize Scoring System
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24/48/72 h
- Score:
- ca. 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- after 8 d
- Remarks on result:
- other: after 20h exposure period
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24/48/72h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- after 8 d
- Remarks on result:
- other: after 20h exposure period
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24/48/72h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: after 20h exposure period
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24/48/72h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: after 20h exposure period
- Irritant / corrosive response data:
- No effect 1, 5 and 15 min after application
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
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