Registration Dossier
Registration Dossier
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EC number: 201-368-7 | CAS number: 81-64-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- One group of 10 male Wister rats (average weight 180-200 g) received a single cutaneous dose of 2500 mg/kg bw Chinizarin techn. tr.. The animals were observed for mortality and clinical signs through day 14.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1,4-dihydroxyanthraquinone
- EC Number:
- 201-368-7
- EC Name:
- 1,4-dihydroxyanthraquinone
- Cas Number:
- 81-64-1
- Molecular formula:
- C14H8O4
- IUPAC Name:
- 1,4-dihydroxy-9,10-dihydroanthracene-9,10-dione
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: 50% lutrol
- Duration of exposure:
- 24 hours
- Doses:
- 2500 mg/kg bw
- No. of animals per sex per dose:
- 10 male rats/dose
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None of the animals died and no signs of intoxication were observed.
- Clinical signs:
- other: None of the animals died and no signs of intoxication were observed.
- Gross pathology:
- No data.
- Other findings:
- No data.
Any other information on results incl. tables
None of the animals died and no signs of intoxication were observed.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- None of the animals died and no signs of intoxication were observed. LD50 > 2500 mg/kg bw (rat, male). According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is therefore not justified.
- Executive summary:
One group of 10 male Wister rats (average weight 180-200 g) received a single cutaneous dose of 2500 mg/kg bw Chinizarin techn. tr.. The animals were observed for mortality and clinical signs through day 14. None of the animals died and no signs of intoxication were observed. LD50 > 2500 mg/kg bw (rat, male).
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