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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
specific investigations: other studies
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: special investigation

Data source

Reference
Reference Type:
publication
Title:
Ueber die laxierende wirkung einiger einfacher anthrachinone mit photodynamischen eigenschaften
Author:
Minker E, Mueller A, Reisch G
Year:
1984
Bibliographic source:
Sci Pharm 52, 91-96 (1984)

Materials and methods

Principles of method if other than guideline:
Several anthraquinones were tested for laxative activity with mice and rats.
GLP compliance:
not specified
Type of method:
in vivo
Endpoint addressed:
other: Laxative activity of anthraquinone

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4-dihydroxyanthraquinone
EC Number:
201-368-7
EC Name:
1,4-dihydroxyanthraquinone
Cas Number:
81-64-1
Molecular formula:
C14H8O4
IUPAC Name:
1,4-dihydroxy-9,10-dihydroanthracene-9,10-dione

Test animals

Species:
other: rats and mice
Strain:
other: CFY-rats and CFLP-mice
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: Methycellulose
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
single application
Frequency of treatment:
single application
Doses / concentrations
Remarks:
Doses / Concentrations:
100, 200 or 400 mg/kg bw
Basis:
nominal conc.

Results and discussion

Details on results:
1,4-dihydroxyanthraquinoe has a laxative effect 12-24 after application in doses of 100 to 200 mg/kg bw. 1,4-anthraquinone was not toxic in the applied dosages and was excreted by the urine.

Applicant's summary and conclusion

Executive summary:

Several anthraquinones were tested for laxative activity with mice and rats. 1,4-dihydroxyanthraquinoe has a laxative effect 12-24 after application in doses of 100 to 200 mg/kg bw. 1,4-anthraquinone was not toxic in the applied dosages and was excreted by the urine.