Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-368-7 | CAS number: 81-64-1
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
A 72h-EC50 of 0.044 mg/L and a 72h-NOEC of 0.00757 mg/L was obtained on the alga Desmodesmus subspicatus.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 0.044 mg/L
- EC10 or NOEC for freshwater algae:
- 0.008 mg/L
Additional information
In order to test acute toxicity to algae of the substance, Desmodesmus subspicatus was exposed to the test solution of 5 nominal concentration of the test substance (0.1, 0.32, 1.0, 3.2 and 10 mg/L) and blank control solution for a period of 72 h under static conditions. The cell densities were measured at 24 hour intervals. Inhibition of the algal population was measured as reduction in growth rate (index r), relative to control cultures grown under identical conditions. A 72h-EC50 of 0.044 mg/L and a 72h-NOEC of 0.00757 mg/L were obtained. The test was performed using the OECD Guideline 201 (Alga, Growth Inhibition Test).
The results are expressed in terms of geometric mean measured concentrations. Effective concentrations ranged from 1.5 % to 1.7 % of nominal values at 0 hours. After 24 hours the highest test item concentration 10 mg/L corresponds to 0.2 % of nominal values while the next test item concentration 3.2 mg/L dropped below the quantification limit (0.0098 mg/L). After 48 hours also the test item concentration 10 mg/L dropped below the quantification limit. Analysis of all test item concentrations after 72 hours of exposure confirms that all concentrations were below the quantification limit.
This toxicity study is classified as acceptable and satisfies the guideline requirements for the actue algae study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
