Registration Dossier
Registration Dossier
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EC number: 418-280-1 | CAS number: 18600-59-4 CYASORB(R) UV-3638 LIGHT STABILISER
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Skin Sensitisation
The skin sensitization was evaluated in a GLP and EU Method B.6 study with Dunkin-Hartley Guinea Pig. 20 Guinea Pig per group were induced with Chiguard 380/Chiguard 380W at concentration of 5% w/v in Alembicol D and challenged at concentration of 30% w/v and 60%w/v Chiguard 380/Chiguard 380W in Alembicol D. Two studies were conducted. In the first study, five animals (i.e. 50 %) showed a positive result. Furthermore it is peculiar that in the second study, although a few animals reacted positive, no further challenge was performed as in the first study.
Migrated from Short description of key information:
Skin sensitisation: sensitising (EU Method B.6, GPMT)
Respiratory sensitisation
Endpoint conclusion
- Additional information:
Migrated from Short description of key information:
No relevant information is available
Justification for classification or non-classification
Based on the available information in the dossier, the substance Chiguard 380/Chiguard 380W (CAS#18600-59-4) need to be classified as Sensitisation (Xi, R43) when considering the criteria outlined in Annex VI of 67/548/EEC and classified as Skin Sens. 1B when considering the criteria outlined in Annex I of 1272/2008/EC and its adaption (EU) No 286/2011.
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