Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 418-280-1 | CAS number: 18600-59-4 CYASORB(R) UV-3638 LIGHT STABILISER
Endpoint summary
Administrative data
Description of key information
Skin Irritation (rabbit): not irritating (ANNEX V, B.4);
Eye irritation (rabbit): not irritating(OECD 405);
Respiratory irritation: no information is available.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin Irritation
The skin irritation was evaluated in a study according to B.4 of ANNEX V (EU test guidelines) with 3 New Zealand white rabbits. 500mg Chiguard 380/Chiguard 380W was applied to the test sites of each rabbit for 4 hours. All animals were examined for signs of erythema and oedema, and the responses scored at 24, 48 and 72 hours after patch removal.At all observation periods erythema and oedema scores 0.
Eye Irritation
The eye irritation was evaluated in a study according to 16 CFR 150 with 3 New Zealand white rabbits. 31.1mg Chiguard 380/Chiguard 380W was applied to the animal. All animals were examined for signs of cornea, iris, conjunctivae and chemosis. The mean score of conjunctivae is 0.17 at 72 hours. And the other mean score were all 0.
Justification for classification or non-classification
From the skin irritation/corrosion study, erythema and oedema scores 0 at all observation periods, so it can be concluded Chiguard 380/Chiguard 380W (CAS# 18600-59-4) does not need to be classified for skin irritation/corrosion according to the criteriadescribed in Regulation (EC) No 1272/2008 and 67/548/EEC.
From the eye irritation study, it can be concluded Chiguard 380/Chiguard 380W (CAS# 18600-59-4) does not need to be classified for eye irritating according to the criteriadescribed in Regulation (EC) No 1272/2008 and 67/548/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
