Registration Dossier
Registration Dossier
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EC number: 418-280-1 | CAS number: 18600-59-4 CYASORB(R) UV-3638 LIGHT STABILISER
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity:
LD50(rat): > 5000 mg/kg bw /day (OECD 401, limit test).
Acute dermal toxicity:
LD50(rabbit): >2000mg/kg bw /day (16 CFR 1500).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute oral toxicity
The acute oral toxicity was evaluated in a well conducted GLP and OECD guideline 401 study (limit study) with Sprague-Dawley Albino rats.10 rats (5 male rats and 5 female rats) were administrated at dose of 5000mg/kg bw/day. All animals survived. Signs seen on the day of dosing in a few animals included wet rales and soft stool. A few animals had decreased food consumption on the day of dosing; this continued in some animals through Day 2. One male had swollen nose on Days 3 and 4. All surviving animals were free of significant abnormalities from Day 3 through termination of the study. The LD50(rat) > 5000mg/kg bw/day was established in this study.(1995)
Acute dermal toxicity
The acute dermal toxicity was evaluated in a key study according to 16 CFR 1500 with albino new Zealand white rabbits. 10 rabbits (6 male rabbits and 4 female rabbits) were administrated at dose of 2000 mg/kg bw/day. Only one male rabbit died on day 4 of the study. Most animals were free of significant signs of systemic toxicity on the day of dosing. LD50(rabbit)>2000kg/kg bw/day was established in this study.(1995)
Justification for classification or non-classification
Based on the available information in the dossier, the substance Chiguard 380/Chiguard 380W (CAS# 18600-59-4) does not need to be classified for acute toxicity when considering the criteria outlined in Annex I of 1272/2008/EC and Annex VI of 67/548/EEC.
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