Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 905-728-0 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Based on both the results of the key study and supporting data from analog substances (triphenyl phosphite (TPP), diisodecyl phenyl phosphite (DDPP) , diphenyl isodecyl phosphite (DPDP)), 2 -EHDPP is expected to be a skin sensitiser. Given the lower responses levels at the 15% v/v concentration compared to the 30% v/v concentration, it does not appear that 2 -EHDPP would be a strong sensitiser. This is further supported by the less than conclusive results from the DPDP GPMT and the fact that DDPP had an EC3 concentration of 40% in a recent LLNA study.
Migrated from Short description of key information:
There are both skin sensitisation studies on 2-EHDPP and several on close phosphite analogs, diphenyl isodecyl phosphite (DPDP) and triphenyl phosphite (TPP) and diisodecyl phenyl phosphite (DDPP). The guinea pig maximisation study of 2-EHDPP showed positive responses in 8 of the 10 test animals at the 30% v/v challenge concentration. The responses were lower at the lower (15% v/v) challenge concentration. The study authors concluded that this substance is a skin sensitiser. These data are further supported by positive LLNA studies on related phosphites.
Justification for classification or non-classification
2 -EHDPP is classified as a skin sensitiser based on test data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
