Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

Based on both the results of the key study and supporting data from analog substances (triphenyl phosphite (TPP), diisodecyl phenyl phosphite (DDPP) , diphenyl isodecyl phosphite (DPDP)), 2 -EHDPP is expected to be a skin sensitiser. Given the lower responses levels at the 15% v/v concentration compared to the 30% v/v concentration, it does not appear that 2 -EHDPP would be a strong sensitiser. This is further supported by the less than conclusive results from the DPDP GPMT and the fact that DDPP had an EC3 concentration of 40% in a recent LLNA study.

Migrated from Short description of key information:
There are both skin sensitisation studies on 2-EHDPP and several on close phosphite analogs, diphenyl isodecyl phosphite (DPDP) and triphenyl phosphite (TPP) and diisodecyl phenyl phosphite (DDPP). The guinea pig maximisation study of 2-EHDPP showed positive responses in 8 of the 10 test animals at the 30% v/v challenge concentration. The responses were lower at the lower (15% v/v) challenge concentration. The study authors concluded that this substance is a skin sensitiser. These data are further supported by positive LLNA studies on related phosphites.

Justification for classification or non-classification

2 -EHDPP is classified as a skin sensitiser based on test data.