Reaction mass of 2-ethylhexyl diphenyl phosphite and bis(2-ethylhexyl) phenyl phosphite and triphenyl phosphite

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1975

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well document study using typical protocols.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

EPA OPP 81-5 (Acute Dermal Irritation)

Principles of method if other than guideline:

US 1964 guideline used - Federal Register 191.11, 17 September 1964.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylhexyl diphenyl phosphite

EC Number:

239-716-5

EC Name:

2-ethylhexyl diphenyl phosphite

Cas Number:

15647-08-2

Molecular formula:

C20H27O3P

IUPAC Name:

phosphorous acid, 2-ethylhexyl diphenyl ester

Test material form:

other: liquid

Test animals

Species:

rabbit

Strain:

New Zealand White

Test system

Type of coverage:

occlusive

Preparation of test site:

other: both abraded and unabraded skin were treated

Vehicle:

unchanged (no vehicle)

Controls:

yes

Amount / concentration applied:

0.5 gram of test material was applied to each test site.

Duration of treatment / exposure:

24-hr exposure

Observation period:

Readings were taken at 24 hours, immediately after removal of wrap, and at 72 hours (48 hours post exposure).

Number of animals:

6 animals

Details on study design:

Scoring for erythema and oedema were done using a standarized 0-4 grading system as described in the guideline.

Results and discussion

In vivo

Results

Irritation parameter:

primary dermal irritation index (PDII)

Basis:

mean

Time point:

other: 72 hours

Score:

1

Irritant / corrosive response data:

Slight erythema was reported in all animals, more on the abraded skin than unabraded skin. No Oedema was reported.

Applicant's summary and conclusion

Interpretation of results:

slightly irritating

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

There was slight irritation in tested rabbits.

Executive summary:

There was slight irritation in tested rabbits. The reported PDII was 1.