Registration Dossier
Registration Dossier
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EC number: 905-728-0 | CAS number: -
Endpoint summary
Administrative data
Description of key information
2-EHDPP has a low order of acute toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 840 mg/kg bw
- Quality of whole database:
- There is a reliable study of acute toxicity for 2-EHDPP and other related phosphites. While all show some signs of acute toxicity, these effects occurred only at massively high doses (well above those used in current guidelines). Overall 2-EHDPP appears to have a low order of acute toxicity.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 8 400 mg/m³ air
- Quality of whole database:
- There is an aerosol inhalation study of DPDP, close analog to 2-EHDPP, though it appears sufficiently valid to evaluate the endpoint.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Additional information
There are acute toxicity data for 2 -EHDPP and is close chemical analog diphenyl isodecyl phosphite (DPDP) for oral, dermal and inhalation routes. The data show a low order of acute toxicity.
Justification for selection of acute toxicity – oral endpoint
While mortality and other effects were observed, they occurred at very high doses that would not be used in current guideline studies. The LD50s were all well above the classification limit of 2000 mg/kg.
Justification for selection of acute toxicity – inhalation endpoint
No effects in a high dose aersol study.
Justification for classification or non-classification
2 -EHDPP has a low order of acute toxicity and does not meet the criteria for classification based on its acute toxicity.
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