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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well document study, following standard protocols.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
EPA OTS 798.1175 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethylhexyl diphenyl phosphite
EC Number:
239-716-5
EC Name:
2-ethylhexyl diphenyl phosphite
Cas Number:
15647-08-2
Molecular formula:
C20H27O3P
IUPAC Name:
phosphorous acid, 2-ethylhexyl diphenyl ester
Test material form:
other: liquid

Test animals

Species:
rat
Strain:
CD-1
Sex:
male/female
Details on test animals or test system and environmental conditions:
Rats were obtained from Charles River UK.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
Rats were deprived of food for 18 hours prior to treatment and for a further 4 hours after treatment. Doses were administered by gastric intubation. All doses were adjusted to maintain a constant volume of 40 mL/kg.
Doses:
1.31, 2.30, 4.00, 6.90 g/kg
No. of animals per sex per dose:
5 male and 5 female
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
3 840 mg/kg bw
Based on:
test mat.
95% CL:
3 080 - 4 780
Mortality:
Only one mortality was seen at doses up to and including 2300 mg/kg. Mortality was seen in 3 female rat and 2 male rats at 4000 mg/kg. All male and female rats in the 6900 mg/kg doses died.
Clinical signs:
other: Clinical observations were observed at doses starting at 4000 mg/kg and up including hypoactivity, piloerection, and incontience

Applicant's summary and conclusion

Interpretation of results:
sligthly toxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The acute effects in this study were generally seen at doses of 4000 mg/kg and higher, though there was one lone fatality at 1310 mg/kg. Such high doses would generally not be used in modern guideline studies.
Executive summary:

The LD50 was determined to be 3840 mg/kg for males and females. These LD50 are well above the level for classification.