Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 230-072-0 | CAS number: 6938-94-9
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- data from handbook or collection of data Experimental data of test substance
- Justification for type of information:
- Experimental data of test substance is from collection of data
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- WoE report is prepared based on the toxicity study of daphnia magna for test chemical 2, 3 and 4.
- GLP compliance:
- no
- Analytical monitoring:
- yes
- Remarks:
- Study 3: - Analytical method: HPLC, - Frequency of analysis: 0th, 7th, 14th, 18th day
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Common name: Daphnia magna
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Test temperature:
- Study 3: 20±1 °C
- Nominal and measured concentrations:
- Study 3: Nominal concentrations: 50.0, 25.0, 12.5, 6.25, 3.13 mg/L (geometric ratio 2.0).
- Details on test conditions:
- Study 3:
- Material, size, headspace, fill volume: test solution volume ca. 1.8 L per vessel,
- Type of flow-through: continuous supply system of test solution,
- No. of organisms per vessel: 20 per concentration (5 per vessel),
- No. of vessels per concentration (replicates): 4,
OTHER TEST CONDITIONS:
- Photoperiod: 16 hours light / 8 hours dark,
- Light intensity: <= 1200 lux - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 5.386 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: other details not known
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- 17.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: 95% CI 16.6 - 18.8 mg/L
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 6.25 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: other details not known
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 46 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: Other details not known
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 14 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: other details not known
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The concentration range of the test chemical based on the surrogate chemical is 5.386-46 mg/L.
- Executive summary:
Data available from various sources for target chemical has been reviewed to determine the toxicity of the test chemical on daphnia magna. The studies are as mentioned below:
Firstly, The study outlines the predection of the test chenical to daphnia magna for the period of 21.0 days. the experiment was run for the period of 21 days. The NOEC of the test chemical to daphnia magna was predicted to be 5.386 mg/L.
Secondly, the data from authoritative database outlines that the test was conducted to understand the effect of test chemical on daphnia magna reproduction. The was conducted based on the OECD guidelines 211. A range of test concentration was selected from 3.13 to 50.0 mg/L with geometric ratio of 2. the test was conducted for the period of 21.0 days in the flow through system. Based on the outcomes median effective concentration of the test chemical on reproduction capacity daphnia magna was 17.6 mg/L.
Another study from the same authoritative database outlines the effect of the test chemical on the reproduction of daphnia magna. The test was conducted in accordance with OECD 211 guidelines. The test was conduced for the period of 21 days and median effective concentration of the test chemial was determied to be >46.0 mg/L.
As the test chemical is readily biodegradable it cannot be classified as per CLP criteria.
Reference
Study 3:
- 50 % Lethal concentration (LC50) to parental Daphnia (21 d): 28.8 mg/L (95 % CL: 24.1 - 34.3 mg/L),
- Lowest observed effect concentration (LOEC) for reproduction: 12.5 mg/L,
Description of key information
The study outlines the predection of the test chenical to daphnia magna for the period of 21.0 days. the experiment was run for the period of 21 days. The NOEC of the test chemical to daphnia magna was predicted to be 5.386 mg/L.
As the test chemical is readily biodegradable it cannot be classified as per CLP criteria.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 5.386 mg/L
Additional information
Data available from various sources for target chemical has been reviewed to determine the toxicity of the test chemical on daphnia magna. The studies are as mentioned below:
Firstly, The study outlines the predection of the test chenical to daphnia magna for the period of 21.0 days. the experiment was run for the period of 21 days. The NOEC of the test chemical to daphnia magna was predicted to be 5.386 mg/L.
Secondly, the data from authoritative database outlines that the test was conducted to understand the effect of test chemical on daphnia magna reproduction. The was conducted based on the OECD guidelines 211. A range of test concentration was selected from 3.13 to 50.0 mg/L with geometric ratio of 2. the test was conducted for the period of 21.0 days in the flow through system. Based on the outcomes median effective concentration of the test chemical on reproduction capacity daphnia magna was 17.6 mg/L.
Another study from the same authoritative database outlines the effect of the test chemical on the reproduction of daphnia magna. The test was conducted in accordance with OECD 211 guidelines. The test was conduced for the period of 21 days and median effective concentration of the test chemial was determied to be >46.0 mg/L.
As the test chemical is readily biodegradable it cannot be classified as per CLP criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
