Diisopropyl adipate

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

Experimental data of various test substance

Justification for type of information:

Experimental data of various test substance is from handbook or collection of data

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

WoE report is prepared based on three toxicity study of aquatic invertebrate for test chemical:
2, 3 and 4 The toxicity of test material was evaluated for aquatic invertebrate

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Daphnia magna

Details on test organisms:

Common name: Water Flea

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

24 h

Remarks on exposure duration:

Study 3and 4 : 48.0 h

Test temperature:

Study 2: 20-22°C

pH:

Study 2: 7-7.5

Nominal and measured concentrations:

Nomial concentration:Study 2: 0-360 mg/L; Study 3:100, 76.9, 59.2, 45.5, 35.0 mg/L (geometric ratio 1.3)

Details on test conditions:

Study2:
Number of species: 20
Age >24 hrs

Reference substance (positive control):

yes

Remarks:

Study 2: K2Cr2O7

Key result

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

151 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: SE : 13

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

46.3 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 95% CI 43.9-50.0 mg/L

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

35 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: Other details not known

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 50 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other: other details not known

Validity criteria fulfilled:

not specified

Conclusions:

The median effetcive concentration of the test chemical to daphnia magna ranges from 46.3 to 151 mg/L.

Executive summary:

Data available from various sources for target chemical has been reviewed to determine the toxicity of the test chemical on daphnia magna. The studies are as mentioned below:

The study 2 from peer reviewed journal outlines the effects of test chemial on Daphnia magna for the period of 24 h. the experiment was conducted inaccordance with OECD 202 guidelines. The test concentrations selected was ranging between 0 -360 mg/L. the median effetcive concentration of the test chemical to daphnia magna is 151 ± 13 mg/L.

Another two studies from authoritative database outlines the effect of the test chemical on the daphnia magna for the period of 48 h. the test was conducted in accordance with OECD 202 guidelines. The median lethal concentration of the test chemical to daphnia magna was determined to be 46.3 and >50 mg/L.

As the test chemical is readily biodegradable it cannot be classified as CLP criteria.

Description of key information

The study outlines the effects of test chemial on Daphnia magna for the period of 24 h. the experiment was conducted inaccordance with OECD 202 guidelines. The test concentrations selected was ranging between 0 -360 mg/L. the median effetcive concentration of the test chemical to daphnia magna is 151 ± 13 mg/L. As the test chemical is readily biodegradable it cannot be classified as CLP criteria.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

151 mg/L

Additional information

Data available from various sources for target chemical has been reviewed to determine the toxicity of the test chemical on daphnia magna. The studies are as mentioned below:

The study 2 from peer reviewed journal outlines the effects of test chemial on Daphnia magna for the period of 24 h. the experiment was conducted inaccordance with OECD 202 guidelines. The test concentrations selected was ranging between 0 -360 mg/L. the median effetcive concentration of the test chemical to daphnia magna is 151 ± 13 mg/L.

Another two studies from authoritative database outlines the effect of the test chemical on the daphnia magna for the period of 48 h. the test was conducted in accordance with OECD 202 guidelines. The median lethal concentration of the test chemical to daphnia magna was determined to be 46.3 and >50 mg/L.

As the test chemical is readily biodegradable it cannot be classified as CLP criteria.