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EC number: 274-798-6 | CAS number: 70714-66-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- Conducted prior to adoption to OECD test guidelines.
- Deviations:
- yes
- Remarks:
- Limited information on test substance, methods, animal/conditions. No information on scoring system used.
- Principles of method if other than guideline:
- Method: other: Insufficient detail to fully assess comparability with OECD guideline.
- GLP compliance:
- no
Test material
- Reference substance name:
- [[(phosphonomethyl)imino]bis[ethane-2,1-diylnitrilobis(methylene)]]tetrakisphosphonic acid
- EC Number:
- 239-931-4
- EC Name:
- [[(phosphonomethyl)imino]bis[ethane-2,1-diylnitrilobis(methylene)]]tetrakisphosphonic acid
- Cas Number:
- 15827-60-8
- Molecular formula:
- C9H28N3O15P5
- IUPAC Name:
- [(bis{2-[bis(phosphonomethyl)amino]ethyl}amino)methyl]phosphonic acid
- Reference substance name:
- [[(phosphonomethyl)imino]bis[ethane-2,1-diylnitrilobis(methylene)]]tetrakis phosphonic acid
- IUPAC Name:
- [[(phosphonomethyl)imino]bis[ethane-2,1-diylnitrilobis(methylene)]]tetrakis phosphonic acid
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: No data
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
IN-LIFE DATES: No data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml (equivalent to 85.2 mg active acid including HCl, although the recommended dose of 0.1 ml was achieved for the formulation, this means that the limit dose for the active acid was not attained. The level of irritation of the anhydrous active acid may therefore be underestimated by this study). - Duration of treatment / exposure:
- 24 hour(s)
- Observation period (in vivo):
- 14 days (10 minutes, 1 hour and 1, 2, 3, 7 and 14 days)
- Number of animals or in vitro replicates:
- Six
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data
- Time after start of exposure: No data
SCORING SYSTEM: Draize.
TOOL USED TO ASSESS SCORE: No data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 hours
- Score:
- ca. 47.9
- Max. score:
- 110
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- 10 minutes: Necrosis in conjunctival sac, slight oedema, copious discharge, slight dullness over cornea.
One hour: No apparent change.
24 hours: Very slight to well defined areas of corneal cloudiness, iris reaction was slow, necrosis in conjunctival sac, slight/moderate oedema, copious discharge containing whitish exudate.
48 to 168 hours: Slight improvement.
14 days: Slight ulceration in lower cornea. - Other effects:
- Immediate, severe discomfort with thrashing about and squealing.
Any other information on results incl. tables
CORNEA
24 hours 30, 20, 15, 20, 20, 30 (very slight to well
defined areas of corneal cloudiness)
48 hours 30, 20, 15, 30, 30, 30
72 hours 30, 40, 20, 30, 40, 30
168 hours 45, 40, 10, 40, 40, 30
IRIS
24 hours 5, 5, 5, 5, 5, 5 (iris reaction slow)
48 hours 5, 5, 5, 5, 5, 5
72 hours 5, 5, 5, 5, 10, 5
168 hours 10, 5, 5, 10, 10, 5
CONJUCTIVAE
24 hours 18, 18, 14, 18, 18, 18 (necrosis in conjunctival
sac)
48 hours 16, 18, 12, 18, 16, 16
72 hours 16, 16, 12, 18, 14, 12
168 hours 16, 12, 8, 16, 12, 10
14 days after dosing: slight ulceration in lower cornea.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- In an eye irritation study (reliability score 4) that was available as a limited summary only, and conducted prior to OECD test guideline and GLP, DTPMP-H was severely irritating to rabbit eyes.
- Executive summary:
In an eye irritation study (reliability score 4) that was available as a limited summary only, and conducted prior to OECD test guideline and GLP, 0.1 ml of undiluted Dequest 2060 was instilled into one eye of each of six New Zealand white rabbits. Although the recommended dose of 0.1 ml was achieved for the formulation, this means that the limit dose for the active acid was not attained. The level of irritation of the anhydrous active acid may therefore be underestimated by this study. However, the presence of HCl in the formulation would be predicted to exacerbate the effect seen. After 24 hours the animals were observed for signs of eye irritation and reactions were graded according to the Draize scoring system. Reactions were graded at 10 minutes, 1, 24, 48, 72 and 168 hours, and 14 days. Immediate, severe discomfort with thrashing about and squealing was observed. Ten minutes after instillation, necrosis of the conjunctival sac, slight oedema, copious discharge, and slight dullness over the cornea were observed. There was no apparent further change after one hour. After 24 hours there were very slight to well defined areas of corneal cloudiness, iris reaction was slow, necrosis in conjunctival sac, slight/moderate oedema and copious discharge containing whitish exudate were noted. There was a slight improvement between 48 and 168 hours. After 14 days slight ulceration in lower cornea was recorded.
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