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EC number: 274-798-6 | CAS number: 70714-66-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- During November 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- Conducted prior to adoption of OECD 401.
- Deviations:
- yes
- Remarks:
- Short acclimatisation period, wide variation in starting body weights, only 5 animals/sex.
- Principles of method if other than guideline:
- Method: other: Hazleton protocol (number P631/22/4/-/553/d/rev.1). The first four doses were in effect a dose-range finding study (only deaths recorded for 48 hours) and the highest dose a limit test.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- [[(phosphonomethyl)imino]bis[(ethylenenitrilo)bis(methylene)]]tetrakisphosphonic acid, sodium salt
- EC Number:
- 244-751-4
- EC Name:
- [[(phosphonomethyl)imino]bis[(ethylenenitrilo)bis(methylene)]]tetrakisphosphonic acid, sodium salt
- Cas Number:
- 22042-96-2
- Molecular formula:
- C9H28N3O15P5.xNa
- IUPAC Name:
- sodium hydrogen [10,10-dihydroxy-10-oxido-2,5,8-tris(phosphonomethyl)-2,5,8-triaza-10-phosphadec-1-yl]phosphonate
- Reference substance name:
- [[(phosphonomethyl)imino]bis[(ethylenenitrilo)bis(methylene)]]tetrakisphos phonic acid, sodium salt
- IUPAC Name:
- [[(phosphonomethyl)imino]bis[(ethylenenitrilo)bis(methylene)]]tetrakisphos phonic acid, sodium salt
- Test material form:
- liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Bantin and Kingman Ltd
- Age at study initiation: No data
- Weight at study initiation: 150 to 250 g
- Fasting period before study: Overnight (18-20 hours)
- Housing: Groups of 2 or 5 in solid-bottomed plastic cages.
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: At least three days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-25
- Humidity (%): 40-60
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): Natural light supplemented with fluorescent lighting during working hours (08.45-17.00)
IN-LIFE DATES: No data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25, 50, 100, 200, 500 mg/ml
- Justification for choice of vehicle: None given
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg - Doses:
- 250, 500, 1000, 2000 and 5000 mg/kg bw. Doses presumed to be given in terms of DTPMP-xNa (not diluted solution), but not to have been corrected for purity, therefore presumed equivalent to 82.5, 165, 330, 660, and 1650 mg active salt/kg bw respectively.
- No. of animals per sex per dose:
- Two (except five at 500 mg/kg bw)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: High dose group only: 14 days
- Frequency of observations and weighing: High dose group only: All animals were observed for overt signs of toxicity or behavioural change at 15 minutes, 1, 2, and 4 hours after treatment and subsequently once daily for 14 days. Individual body weights were recorded on the day before treatment, on the day of treatment and 14 days after treatment.
- Necropsy of survivors performed: yes, in high dose group only.
- Other examinations performed: gross pathology. - Statistics:
- None
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 5 000 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 1 650 mg/kg bw
- Based on:
- act. ingr.
- Remarks:
- active salt
- Remarks on result:
- other: equivalent to 1303 mg active acid/kg bw
- Mortality:
- No animals died during the observation period.
- Clinical signs:
- other: No clinical signs.
- Gross pathology:
- No animals died so no necropsies were performed.
- Other findings:
- None reported.
Any other information on results incl. tables
Calculation of equivalent dose:
Based on DTPMP-xNa composed of 33% active salt including
minor components, remainder water (MSDS).
For purposes of comparison with other Group 3 results, ≥1650
mg active salt/kg bw is equivalent to ≥1303 mg parent acid
(DTPMP, CAS 15827-60-8)/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- No mortality or clinical signs of toxicity occurred in any of the test animals.
- Conclusions:
- In an acute oral toxicity study, conducted prior to the adoption of OECD Test Guidelines and GLP, the LD50 for DTPMP-xNa was ≥5000 mg/kg bw (equivalent to ≥1650 mg active salt/kg bw and ≥1303 mg active acid/kg bw) in the rat.
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