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EC number: 274-798-6 | CAS number: 70714-66-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Limited detail on test substance, methods and animals/conditions. 24-hour exposure duration under occlusive dressing.
- Principles of method if other than guideline:
- Method: other: Insufficient detail to fully assess comparability with OECD guideline.
- GLP compliance:
- no
Test material
- Reference substance name:
- [[(phosphonomethyl)imino]bis[ethane-2,1-diylnitrilobis(methylene)]]tetrakisphosphonic acid
- EC Number:
- 239-931-4
- EC Name:
- [[(phosphonomethyl)imino]bis[ethane-2,1-diylnitrilobis(methylene)]]tetrakisphosphonic acid
- Cas Number:
- 15827-60-8
- Molecular formula:
- C9H28N3O15P5
- IUPAC Name:
- [(bis{2-[bis(phosphonomethyl)amino]ethyl}amino)methyl]phosphonic acid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: No data
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
IN-LIFE DATES: No data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml (although the recommended dose of 0.5 ml was achieved for the formulation, this means that the limit dose for the active acid was not attained. The level of irritation of the anhydrous active acid may therefore be underestimated by this study.However, the presence of HCl in the formulation would be predicted to exacerbate the effect seen). - Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- Seven days (1, 24, 48, 72, 120 and 168 hours)
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: No data
- % coverage: No data but 1X1 inch square patch used
- Type of wrap if used: Occlusive plastic wrap.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No Data
- Time after start of exposure: No data
SCORING SYSTEM: Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Average maximum score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 1
- Max. score:
- 8
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- other: Individual animal readings were not available.
- Irritant / corrosive response data:
- After one hour there were no skin changes, but by 24 hours there was grade 1 erythema (no oedema) in all three animals. This erythema had disappeared by 48 hours.
- Other effects:
- None
Any other information on results incl. tables
Scored responses were as follows.
1 hour 0,0,0
24 hours 1,1,1 (barely perceptible erythema; no oedema)
48-168 hours 0,0,0
The average maximum score was 1.0 out of a possible 8.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a skin irritation study (reliability score 2) conducted prior to the adoption of OECD test guidelines and GLP, DTPMP-H was mildly irritating to rabbit skin.
- Executive summary:
In a skin irritation study (reliability score 2) conducted prior to the adoption of OECD test guidelines and GLP, 0.5 ml undiluted 58% w/w solution of diethylenetriamine penta(methylene phosphonic acid) was applied to the clipped, intact skin of three New Zealand white rabbits for 24 hours. A 1x1 inch square patch was used and covered with an occlusive dressing. Skin reactions were scored at 1, 24, 48, 72, 120 and 168 hours using the Draize scoring system. After one hour there were no skin changes, but by 24 hours there was grade 1 erythema (no oedema) in all three animals. This erythema had disappeared by 48 hours. Therefore the test substance was mildly irritating to the skin of rabbits.
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