Registration Dossier
Registration Dossier
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EC number: 415-430-8 | CAS number: 86403-32-9 CYASORB UV-3853 LIGHT STABILIZER; DASTIB 845; SANDUVOR 845
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
The toxicokinetic behaviour of the substance was investigated based on a review of the published literature. Key parameters are its low water solubility and high octanol-water partition coefficient. It is readily biodegraded through cleavage of the ester linkage. Bioaccumulation potential cannot easily be determined, but the substance meets the screening criteria for bioaccumulative.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
The literature on the toxicokinetics of EC 415-430-8 was reviewed. Its low water solubility and high molecular weight polymeric structure suggests a lower potential for absorption across the skin, gastrointestinal tract and respiratory tract compared to the fatty acid esters, the digestion products. These are readily absorbed in the gastrointestinal tract. Fatty acid esters are taken up in the plasma and distributed to highly perfused tissues. Fatty acid esters are also likely to be distributed in the body fat and in breast milk. Any fatty acid esters formed will undergo acylation, desaturation and β-oxidation. EC 415-430-8 (the fatty acid esters) and the products of metabolism are not likely to be toxic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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