Registration Dossier
Registration Dossier
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EC number: 415-430-8 | CAS number: 86403-32-9 CYASORB UV-3853 LIGHT STABILIZER; DASTIB 845; SANDUVOR 845
Endpoint summary
Administrative data
Description of key information
The substance is not considered irritating to the skin. It is irritating to mucous membranes, causing severe damage to the eye and possible irritation to the respiratory tract.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
One study obtained from ECHA through the SNIF Inquiry process indicated that slight to moderate irritation occurred inconsistently in 3 rabbits after a semiocclusive exposure of 4 hours duration, but the effect was fully reversible within 11 days.
Experimental data in rabbits indicates that the substance causes severe irritation to the eye, including corneal opacity, although there is no data to draw a conclusion on the permanence of this effect due to the early termination of the study for humane reasons.
There is no experimental evidence regarding respiratory irritation, however the substance is reasonably anticipated to be a mucous-membrane irritant, and thus may cause respiratory irritation if inhaled. However, because the substance is a waxy substance at normal use temperatures, inhalation of vapours or dust is not considered a viable exposure route. Observations in humans are lacking which may confirm respiratory irritation. Furthermore, in the acute inhalative toxicity tests, no signs of irritation were described. As an overall conclusion, respiratory hazard is not anticipated.
Effects on eye irritation: highly irritating
Justification for classification or non-classification
The substance is not classified as a dermal irritant, although due to its sensitising properties, recommendations to prevent dermal contact (by personal protection such as gloves) will also protect against potential dermal irritation. It is classified as a Category 1 eye irritant via irritation to mucous membranes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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