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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
12 August to 08 September 2022 (experimental phase)
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
conducted under GLP conditions
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2009
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: Knudsen cell
Key result
Temp.:
20 °C
Vapour pressure:
0.001 Pa
Temp.:
25 °C
Vapour pressure:
0.002 Pa

Results Positive Control: Diethylphthalate














Vapour pressure (positive control) at 30°C:



1.48*10-1 Pa



Criterion for the vapour pressure of the positive control at 30°C



0.44*10-1 - 2.44*10-1 Pa



The vapour pressure met the validity criteria. Therefore, the study can be considered as valid.

Conclusions:
The vapour pressure of the test item was determined at three different temperatures (45, 60 and 75 °C) according to OECD 104 resp. EU A.4 using the effusion method (weight loss). Experiment 1 and 5 (nominal temperature 30 and 90 °C) showed only a poor reproducible weight loss. When visible contaminations, caused by explosive evaporation of the test item, were observed, the cells were meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, these measurements were not used for calculations.
Three respectively two (for the second experiment with nominal temperature of 45 °C) ex- periments at three distinctly different temperatures could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good repeatability, giving relative staondard deviations of less than 11 % (limit value from the guideline 30 %) and good correlation.
Therefore, the result of the test can be considered valid.
Executive summary:

The vapour pressure of the test item was determined following EU A.4 using the effusion method (weight loss).


For the test item, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:


Vapour pressure at 20 °C: 7.48 * 10^-04 Pa


Vapour pressure at 25 °C: 1.54 * 10^-03 Pa

Description of key information

The vapour pressure of the test item was determined following EU A.4 using the effusion method (weight loss).


For the test item, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:


Vapour pressure at 20 °C: 7.48 * 10^-04 Pa


Vapour pressure at 25 °C: 1.54 * 10^-03 Pa

Key value for chemical safety assessment

Vapour pressure:
0.001 Pa
at the temperature of:
20 °C

Additional information