Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
The read-across from the two source substances is considered to give a reliable estimation of the acute oral toxicity potential of the target substance. Both source substances are found to have an LD50oral >2000 mg/kg bw and >16000 mg/kg bw, respectively.
The LD50 oral of 9000 mg/kg bw in the read-across study has been estimated for hazard classification and chemical safety assessment.
In conclusion, a LD50oral >2000 mg/kg bw is taken for the target substance.
According to the LD50 values described above, both analogues and the target substance are associated with the same GHS/CLP classification (not classified).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- A detailed read-across justification in-line with the ECHA RAAF guidelines is provided as an attached document.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The read-across from the two source substances is considered to give a reliable estimation of the acute oral toxicity potential of the target substance. Both source substances are found to have an LD50oral >2000 mg/kg bw and >16000 mg/kg bw, respectively.
The LD50 oral of 9000 mg/kg bw in the read-across study has been estimated for hazard classification and chemical safety assessment.
In conclusion, a LD50oral >2000 mg/kg bw is taken for the target substance.
According to the LD50 values described above, both analogues and the target substance are associated with the same GHS/CLP classification (not classified).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 2 000 mg/kg bw
Additional information
Justification for classification or non-classification
Based on the data available, the substance has shown no acute systemic toxicity potential and should therefore not be classified for acute toxicity according to the (EC) No 1272/2008 Regulation (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
