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EC number: - | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From November 29, 2021 to February 08, 2022
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- conducted under GLP conditions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- yes
- Remarks:
- See section 'Any other information on materials and methods incl. tables'
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- See section 'Any other information on materials and methods incl. tables'
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- yes
- Remarks:
- See section 'Any other information on materials and methods incl. tables'
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 1.01 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 34.9 mg/L
- Incubation duration:
- 168 h
- Temp.:
- 20 °C
- pH:
- 6.45
- Remarks on result:
- other: Average of 96 and 168 hours sample solubility in pure water
- Details on results:
- There is no significant change (6.2%) of the measured concentrations with time for the last two samplings (96h and 168h), and therefore according to the GEeD Guideline No. 105 as this difference is lower than 15%, it can be concluded that the system reached the equilibrium.
Thus, the results from the last two samples obtained were averaged to give the water solubility of the test item.
After rounding off:
Solubility of the test item in water: 1.01 mg/L at 20°C - Conclusions:
- Solubility of the test item in water: 1.01 mg/L at 20°C
- Executive summary:
The solubility of the test item in ultrapure water was determined according to the GECD Guideline No. 105 (flask method), based on analysis of the two isomers of the test item.
The result is:
Solubility of the test item in water: 1.01 mg/l at 20°C
This result corresponds to the saturation mass concentration of the test item in ultrapure water at 20°C.
Reference
Description of key information
The solubility of GR-87-6331 in ultrapure water was determined according to the GECD Guideline No. 105 (flask method), based on analysis of the two isomers of GR-87-6331.
The result is:
Solubility of GR-87-6331 in water: 1.01 mg/l at 20°C
This result corresponds to the saturation mass concentration of GR-87-6331 in ultrapure water at 20°C.
Key value for chemical safety assessment
- Water solubility:
- 1.01 mg/L
- at the temperature of:
- 20 °C
Additional information
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