(4S)-1-methyl-4-(6-methylhepta-1,5-dien-2-yl)cyclohexene

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Federal Register 38 No. 187 § 1500.41

Version / remarks:

27.09.73

Principles of method if other than guideline:

Test substance was dermally applied undiluted for 24 hours on 6 rabbits under occlusive conditions.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-methyl-6-(4-methylcyclohex-3-en-1-ylidene)hept-2-ene

EC Number:

207-805-8

EC Name:

2-methyl-6-(4-methylcyclohex-3-en-1-ylidene)hept-2-ene

Cas Number:

495-62-5

Molecular formula:

C15H24

IUPAC Name:

4-(1,5-dimethylhex-4-en-1-ylidene)-1-methylcyclohexene

Constituent 2

Reference substance name:

(4S)-1-methyl-4-(6-methylhepta-1,5-dien-2-yl)cyclohexene

EC Number:

610-461-5

Cas Number:

495-61-4

Molecular formula:

C15H24

IUPAC Name:

(4S)-1-methyl-4-(6-methylhepta-1,5-dien-2-yl)cyclohexene

Constituent 3

Reference substance name:

6-methyl-2-(4-methylcyclohex-3-enyl)hept-2,5-diene

EC Number:

241-610-9

EC Name:

6-methyl-2-(4-methylcyclohex-3-enyl)hept-2,5-diene

Cas Number:

17627-44-0

Molecular formula:

C15H24

IUPAC Name:

4-(1,5-dimethylhexa-1,4-dien-1-yl)-1-methylcyclohexene

Test animals

Species:

rabbit

Strain:

Vienna White

Remarks:

Gaukler

Details on test animals or test system and environmental conditions:

- Mean weight at study initiation: 2.8 kg

Test system

Type of coverage:

occlusive

Preparation of test site:

other:

Remarks:

intact and abraded skin

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

applied undiluted

Duration of treatment / exposure:

24 hours

Observation period:

72 hours

Number of animals:

6 (4 males, 2 females)

Details on study design:

SCORING SYSTEM: according to DRAIZE, J.H. (1959): Dermal Toxicity. In: FDA - Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics.

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Remarks:

mean

Basis:

animal: 1-6

Time point:

24/48/72 h

Score:

2.2

Max. score:

4

Reversibility:

not fully reversible within: 72h

Results 2

Irritation parameter:

edema score

Remarks:

mean

Basis:

animal: 1-6

Time point:

24/48/72 h

Score:

1.8

Max. score:

4

Reversibility:

not fully reversible within: 72h

Any other information on results incl. tables

Erythema and edema scores (intact skin)

Readings	Animal	Erythema	Edema	Further findings
24h	1	2	3
	2	2	3
	3	3	3
	4	2	3
	5	2	0
	6	2	3
48h	1	2	2
	2	2	3
	3	3	2
	4	2	2
	5	2	0
	6	2	2
72h	1	2	0
	2	2	2
	3	3	2
	4	2	2
	5	2	0
	6	2	0
Mean (24h-72h)	1	2.0	1.7
	2	2.0	2.7
	3	3.0	2.3
	4	2.0	2.3
	5	2.0	0.0
	6	2.0	1.7
Mean (24h-72h)	all animals	2.2	1.8

Results on abraded skin not provided (not relevant for assessment).