(4S)-1-methyl-4-(6-methylhepta-1,5-dien-2-yl)cyclohexene

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Method: BASF-Test; The test was performed according to Smith et al. (1944). J. Ind. Hyg. Tox. 26: 269

GLP compliance:

no

Test type:

other: inhalation hazard test

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-methyl-6-(4-methylcyclohex-3-en-1-ylidene)hept-2-ene

EC Number:

207-805-8

EC Name:

2-methyl-6-(4-methylcyclohex-3-en-1-ylidene)hept-2-ene

Cas Number:

495-62-5

Molecular formula:

C15H24

IUPAC Name:

4-(1,5-dimethylhex-4-en-1-ylidene)-1-methylcyclohexene

Constituent 2

Reference substance name:

(4S)-1-methyl-4-(6-methylhepta-1,5-dien-2-yl)cyclohexene

EC Number:

610-461-5

Cas Number:

495-61-4

Molecular formula:

C15H24

IUPAC Name:

(4S)-1-methyl-4-(6-methylhepta-1,5-dien-2-yl)cyclohexene

Constituent 3

Reference substance name:

6-methyl-2-(4-methylcyclohex-3-enyl)hept-2,5-diene

EC Number:

241-610-9

EC Name:

6-methyl-2-(4-methylcyclohex-3-enyl)hept-2,5-diene

Cas Number:

17627-44-0

Molecular formula:

C15H24

IUPAC Name:

4-(1,5-dimethylhexa-1,4-dien-1-yl)-1-methylcyclohexene

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- A saturated atmosphere was generated by bubbling 200 l/h air at 20 ° C through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 7 hours.

TEST ATMOSPHERE
- No analytical determination of the atmosphere concentration was performed. The nominal concentration was calculated as the quotient of the amount of test substance weight loss during the exposure and the amount of air used during the exposure.

Analytical verification of test atmosphere concentrations:

no

Remarks:

concentration was estimated based on the test substance weight loss

Duration of exposure:

7 h

Concentrations:

13.74 mg/l

No. of animals per sex per dose:

6

Control animals:

other: not applicable

Details on study design:

- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs and body weight
- Duration of observation period following administration: 14 days

Results and discussion

Mortality:

No mortality within 7h of exposure

Clinical signs:

other: no effects observed

Body weight:

normal bw development

Gross pathology:

No test substance related effects observed