Registration Dossier
Registration Dossier
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EC number: 610-461-5 | CAS number: 495-61-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-methyl-6-(4-methylcyclohex-3-en-1-ylidene)hept-2-ene
- EC Number:
- 207-805-8
- EC Name:
- 2-methyl-6-(4-methylcyclohex-3-en-1-ylidene)hept-2-ene
- Cas Number:
- 495-62-5
- Molecular formula:
- C15H24
- IUPAC Name:
- 4-(1,5-dimethylhex-4-en-1-ylidene)-1-methylcyclohexene
- Reference substance name:
- (4S)-1-methyl-4-(6-methylhepta-1,5-dien-2-yl)cyclohexene
- EC Number:
- 610-461-5
- Cas Number:
- 495-61-4
- Molecular formula:
- C15H24
- IUPAC Name:
- (4S)-1-methyl-4-(6-methylhepta-1,5-dien-2-yl)cyclohexene
- Reference substance name:
- 6-methyl-2-(4-methylcyclohex-3-enyl)hept-2,5-diene
- EC Number:
- 241-610-9
- EC Name:
- 6-methyl-2-(4-methylcyclohex-3-enyl)hept-2,5-diene
- Cas Number:
- 17627-44-0
- Molecular formula:
- C15H24
- IUPAC Name:
- 4-(1,5-dimethylhexa-1,4-dien-1-yl)-1-methylcyclohexene
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gassner
- Mean weights at study initiation: 200 g (males), 160 g (females)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 0.5%, 5%, 20% and 50% emulsion of 0.5% aqueous carboxymethylcellulose formulation
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg
- Doses:
- 50, 500, 2000, 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 males/ 5 females (for 50 and 5000 mg/kg bw)
2 females (for 500 and 2000 mg/kg bw) - Control animals:
- other: not applicable
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Clinical signs including body weight : yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortality observed
- Clinical signs:
- other: Excitation (day 1) at 5000 mg/kg bw. No other clinical signs observed.
- Gross pathology:
- No test substance related findings
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
