Registration Dossier
Registration Dossier
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EC number: 610-461-5 | CAS number: 495-61-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- only 1 dose tested
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-methyl-6-(4-methylcyclohex-3-en-1-ylidene)hept-2-ene
- EC Number:
- 207-805-8
- EC Name:
- 2-methyl-6-(4-methylcyclohex-3-en-1-ylidene)hept-2-ene
- Cas Number:
- 495-62-5
- Molecular formula:
- C15H24
- IUPAC Name:
- 4-(1,5-dimethylhex-4-en-1-ylidene)-1-methylcyclohexene
- Reference substance name:
- (4S)-1-methyl-4-(6-methylhepta-1,5-dien-2-yl)cyclohexene
- EC Number:
- 610-461-5
- Cas Number:
- 495-61-4
- Molecular formula:
- C15H24
- IUPAC Name:
- (4S)-1-methyl-4-(6-methylhepta-1,5-dien-2-yl)cyclohexene
- Reference substance name:
- 6-methyl-2-(4-methylcyclohex-3-enyl)hept-2,5-diene
- EC Number:
- 241-610-9
- EC Name:
- 6-methyl-2-(4-methylcyclohex-3-enyl)hept-2,5-diene
- Cas Number:
- 17627-44-0
- Molecular formula:
- C15H24
- IUPAC Name:
- 4-(1,5-dimethylhexa-1,4-dien-1-yl)-1-methylcyclohexene
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Mean weight at study initiation: 2.4 kg (males); 2.5 kg (females)
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- clipped back skin
- Area of exposure: 50 cm2
- Type of wrap if used: parchment paper and bandage - Duration of exposure:
- 24 hours
- Doses:
- 200 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- other: not applicable
- Details on study design:
- - Duration of observation period following administration: 4 days
- Necropsy of survivors performed:no
- Clinical signs determined: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 mg/kg bw
- Mortality:
- No mortality observed
- Clinical signs:
- other: Erythema and edema 24h after application, observed until the end of the observation period (4 days)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
