ALFERROCK

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Acute Toxicity Tests on 113 Environmental Chemicals

Author:

Hasegawa, R.

Year:

1989

Bibliographic source:

Sci. Rep. Res. Inst. Tohoku Univ.,-C, Vol 36, Nos 1-4

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Aluminium chloride

EC Number:

231-208-1

EC Name:

Aluminium chloride

Cas Number:

7446-70-0

IUPAC Name:

aluminum trichloride

Test material form:

not specified

Details on test material:

- Name of test material (as cited in study report): Aluminum chloride

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Shizuoka Laboratory Animal Center (Hamamatsu, Japan)
- Age at study initiation: 6 weeks
- Fasting period before study: yes, 15 hours before treatment
- Diet (e.g. ad libitum): regular laboratory chow
- Acclimation period: 1 week

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

water

Details on oral exposure:

N.A.

Doses:

At least six increasing dose levels were selected and tested to confirm both LD0 and LD100 values.

No. of animals per sex per dose:

5

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Other: Clinical signs and symptoms were monitored during the experimental period. Anatomical examination was performed immediately after death or at terminal sacrifice on day 14.

Statistics:

Lichtfield and Wilcoxon method.

Results and discussion

Effect levels

Effect levels 1

Sex:

female

Dose descriptor:

LD50

Effect level:

3 470 mg/kg bw

Based on:

test mat.

Effect levels 2

Sex:

male

Dose descriptor:

LD50

Effect level:

3 450 mg/kg bw

Based on:

test mat.

Mortality:

Mortality occured, but no detailed information was provided, except the LD50 value for male and female rats

Clinical signs:

other: Hematuria and bloody stool

Gross pathology:

congestion of stomach and brain

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

In an acute oral toxicity test the LD50 in Wistar rats after treatment with aluminium chloride was 3450 mg/kg bw for males and 3470 mg/kg bw for females, respectively.

Executive summary:

In an acute oral toxicity study young adult Wistar rats (5 animals per sex and dose) were orally exposed to aluminium chloride in water at six increasing dose levels to confirm both LD0 and LD100 values. Animals were observed for 14 days. The treatment related clinical signs were hematuria and bloody stool. Pathology abnormalities observed were congestion of stomach and brain. The oral LD50 value in was considered to be 3470 mg/kg bw and 3450 mg/kg bw, for females and males, respectively.