Registration Dossier
Registration Dossier
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EC number: 213-361-6 | CAS number: 939-48-0
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Experiment conducted prior to establishment of guideline; documentation is incomplete but conducted by a reputable industry laboratory.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Isopropyl benzoate
- EC Number:
- 213-361-6
- EC Name:
- Isopropyl benzoate
- Cas Number:
- 939-48-0
- Molecular formula:
- C10H12O2
- IUPAC Name:
- propan-2-yl benzoate
- Reference substance name:
- 13-361-6
- IUPAC Name:
- 13-361-6
- Reference substance name:
- propan-2-yl benzoate
- IUPAC Name:
- propan-2-yl benzoate
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material: Isopropyl Benzoate
Constituent 1
Constituent 2
Constituent 3
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No environmental conditions data is provided in the study report.
Study design: in vivo (LLNA)
- Vehicle:
- other: Acetone
- Concentration:
- 3% w/v, 10% w/v and 30% w/v.
- No. of animals per dose:
- No details
- Details on study design:
- A sample of Isopropyl Benzoate was assessed for its skin sensitisation potential using the mouse Local Lymph Node Assay. The assay determines
the level of T lymphocyte proliferation in the lymph nodes drainage at the site of chemical application, by measuring the amount of radiolabelled thymidine incorporated into the dividing cells. The test substance was applied as 3%, 10% or 30% w/v preparations in Acetone. - Positive control substance(s):
- not specified
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: see table below
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: see table below
Any other information on results incl. tables
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Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- IPB is a potential sensitizer in the conditions of the test.
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